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Dehydroepiandroster...
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Virkki, Liisa M
(författare)
Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's Syndrome.
- Artikel/kapitelEngelska2010
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LIBRIS-ID:oai:gup.ub.gu.se/118583
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https://gup.ub.gu.se/publication/118583URI
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https://doi.org/10.1002/acr.20022DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105296URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134993URI
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OBJECTIVE: Primary Sjögren's syndrome (SS) is characterized by fatigue and low levels of serum dehydroepiandrosterone/dehydroepiandrosterone sulfate (DHEA/DHEAS). Our aim was to study whether SS patients with severe fatigue and low serum DHEAS values benefit from DHEA substitution (50 mg/day). METHODS: A multicenter, investigator-based, powered, randomized controlled clinical trial (crossover, washout design) using fatigue as the primary outcome measure was performed on patients with primary SS (n = 107) who had a general fatigue score > or =14 on the 20-item Multiple Fatigue Inventory (MFI-20), combined with age- and sex-adjusted serum DHEAS values below the mean. Fatigue was assessed using MFI-20 subscales, i.e., general fatigue, physical fatigue, mental fatigue, reduced motivation, and activity (scale 4-20), and with a visual analog scale (VAS; scale 0-100). RESULTS: In an intent-to-treat analysis, a 50-mg DHEA substitution dose and placebo similarly improved fatigue. All of the MFI-20 subscales and the fatigue VAS improved from the baseline levels as a result of treatment (P < 0.001), but with negligible differences between these 2 treatments. The mean between-treatment difference was -0.1 for general fatigue (the primary outcome measure), 0.0 for physical fatigue, 0.0 for mental fatigue, 0.0 for reduced motivation, 0.3 for reduced activity, and 2.2 for the fatigue VAS. None of these differences was statistically significant. CONCLUSION: Similar to earlier results using pharmacologic doses, substitution treatment with 50 mg of DHEA in DHEA-deficient and severely tired primary SS patients does not help against fatigue better than placebo. This may relate to the prohormone nature of DHEA and its recently described defective intracrine tissue-specific conversion to active sex steroids in SS.
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Porola, Pauliina
(författare)
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Forsblad d'Elia, Helena,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Dept of Rheumatology and Inflammation Research, Sahlgrenska Academy, Göteborgs universitet(Swepub:umu)hefo0034
(författare)
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Valtysdottir, SigridurUppsala universitet,Institutionen för medicinska vetenskaper,Reumatologi
(författare)
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Solovieva, Svetlana A
(författare)
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Konttinen, Yrjö T
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Arthritis care & research: Wiley62:1, s. 118-242151-46582151-464X
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