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Diurnal variations ...
Diurnal variations in twenty-four-hour energy expenditure during growth hormone treatment of adults with pituitary deficiency.
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- Stenlöf, Kaj, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Johansson, J O (författare)
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- Lönn, Lars, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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visa fler...
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- Sjöström, Lars (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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Bengtsson, B A (författare)
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - 0021-972X. ; 82:4, s. 1255-60
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The effects of growth hormone (GH) treatment on 24-h energy expenditure (EE) were studied in a open trial over a period of 4 weeks. Five subjects, four men and one woman, with a history of complete GH deficiency were included. All the subjects were examined on 2 consecutive days on baseline and, thereafter, at six occasions during a period of 1 month (days 1, 2, 5, 8, 15, and 30). The dose of GH was 0.25 U/kg.week, administered sc once a day in the evening. EE was determined in a chamber for indirect calorimetry. Body composition was determined with dual-energy x-ray absorptiometry and computed tomography using a four-scan technique. Blood samples were examined using well-established RIAs. During the first 2 weeks, 24-h EE increased by 6 +/- 3% (range 1-8%) from 40.9 +/- 4.8 to 42.9 +/- 4.8 kcal/24 h.kg (P < 0.05), sleeping metabolic rate by 14 +/- 3% (range 10-18%) from 28.4 +/- 1.9 to 32.9 +/- 2.2 kcal/24h.kg (P < 0.001), and basal metabolic rate by 11 +/- 7% (range 0-18%) from 29.6 +/- 2.4 to 33.3 +/- 2.6 kcal/24h.kg (P < 0.05). No change was found in daytime EE. The increase in EE covaried with changes in insulin-like growth factor 1, the free T3/free T4 ratio, insulin-like growth factor-binding protein-3, and the aminoterminal procollagen III peptide but not with changes in body composition. It is suggested that the stimulating effect of GH on EE occurs gradually during a 2-week period and is only detectable during night and morning hours, when significant levels of GH occur.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Adult
- Biological Markers
- Body Composition
- Circadian Rhythm
- Energy Metabolism
- Female
- Human Growth Hormone
- deficiency
- therapeutic use
- Humans
- Insulin-Like Growth Factor Binding Protein 3
- blood
- Insulin-Like Growth Factor I
- metabolism
- Male
- Middle Aged
- Peptide Fragments
- blood
- Pituitary Diseases
- drug therapy
- pathology
- Procollagen
- blood
- Thyroid Hormones
- blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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