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Effects of recombin...
Effects of recombinant human growth hormone on basal metabolic rate in adults with pituitary deficiency.
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- Stenlöf, Kaj, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Sjöström, Lars (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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- Lönn, Lars, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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- Bosaeus, Ingvar, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk näringslära,Institute of Internal Medicine, Dept of Clinical Nutrition
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Kvist, H (författare)
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Tölli, J (författare)
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Lindstedt, G (författare)
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Bengtsson, B A (författare)
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(creator_code:org_t)
- 1995
- 1995
- Engelska.
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Ingår i: Metabolism: clinical and experimental. - 0026-0495. ; 44:1, s. 67-74
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The effect of recombinant human growth hormone (rhGH) on basal metabolic rate (BMR) was studied in a placebo-controlled, double-blind, crossover trial. Ten patients with a history of complete pituitary insufficiency were randomized for 26 weeks in each period. Three patients were excluded due to withdrawal, fever, and claustrophobia, respectively. All patients had received adrenal, thyroid, and gonadal substitution therapy for at least 1 year before the study. The dose of rhGH was 0.25 to 0.5 U/kg/wk, administered subcutaneously once a day in the evening. BMR was determined by indirect calorimetry in a computerized ventilated open-hood system. Body composition was examined using four different methods--computed tomography (CT), tritium dilution, 40K determinations, and total body nitrogen (TBN) measured with neutron activation. The body composition data have previously been reported. Fat-free mass (FFM) increased and body fat (BF) decreased during the first 6 weeks of rhGH treatment, but no further changes in body composition occurred between 6 and 26 weeks. Baseline BMRs in GH-deficient (GHD) patients were in the lower part of the reference range, but BMR and the ratio between BMR and FFM (BMR/FFM) were not significantly lower than in a carefully selected control group. BMR increased between 0 and 6 weeks (mean +/- SD: from 6.68 +/- 1.55 to 7.75 +/- 1.35 MJ/24 h, P < .001) and then remained unchanged between 6 and 26 weeks. The increase in BMR was closely related to the increase in FFM (r = .91, P < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Adult
- Basal Metabolism
- drug effects
- Body Composition
- Cross-Over Studies
- Double-Blind Method
- Female
- Growth Hormone
- pharmacology
- Humans
- Lipid Metabolism
- Male
- Middle Aged
- Oxidation-Reduction
- drug effects
- Peptide Fragments
- metabolism
- Pituitary Diseases
- metabolism
- pathology
- Procollagen
- metabolism
- Recombinant Proteins
- Reference Values
- Thyroid Hormones
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Stenlöf, Kaj, 19 ...
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Sjöström, Lars
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Lönn, Lars, 1956
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Bosaeus, Ingvar, ...
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Kvist, H
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Tölli, J
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visa fler...
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Lindstedt, G
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Bengtsson, B A
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Metabolism: clin ...
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Göteborgs universitet