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Intracoronary beta2...
Intracoronary beta2 receptor activation induces dynamic local t-PA release in the pig.
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- Osterlund, Barbro (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Jern, Christina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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Seeman-Lodding, Helene (författare)
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- Johansson, Göran (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Häggmark, Söran (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Broome, M. (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Biber, Björn (författare)
- Umeå universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Thrombosis and haemostasis. - 0340-6245 .- 2567-689X. ; 90:5, s. 796-802
- Relaterad länk:
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http://www.ncbi.nlm....
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- To investigate beta2 -adrenergic agonist-mediated effects on coronary fluxes of local fibrinolytic factors, healthy anaesthetised and instrumented pigs (n=10) were studied during infusion of isoprenaline (IPR) into the left main coronary artery. Coronary net fluxes of total t-PA antigen, active t-PA and total PAI-1 antigen were determined at baseline and at 3, 5, 7 and 10 minutes of IPR infusion. During IPR, net release of total t-PA increased in a biphasic pattern with transiently high levels at 3 (+440 %) and 7 minutes (+620%) and returned towards baseline at 10 minutes. Net coronary release of active t-PA increased with maximum levels at 3 minutes (+50%). Baseline coronary net flux of total PAI -1 showed a decrease which was most pronounced at 10 minutes. To conclude, a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Adrenergic Agonists
- pharmacology
- Animals
- Catheterization
- Coronary Vessels
- metabolism
- physiology
- Female
- Fibrinolysis
- Hemodynamics
- drug effects
- Isoproterenol
- pharmacology
- Kinetics
- Plasminogen Activator Inhibitor 1
- blood
- Receptors
- Adrenergic
- beta-2
- agonists
- blood
- Swine
- Tissue Plasminogen Activator
- blood
- Adrenergic Agonists/*pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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