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The Swedish Reflux ...
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Brandström, Per,1959Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
(författare)
The Swedish Reflux Trial in Children: III. Urinary Tract Infection Pattern.
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Ovid Technologies (Wolters Kluwer Health),2010
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/122373
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https://gup.ub.gu.se/publication/122373URI
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https://doi.org/10.1016/j.juro.2010.01.061DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120602642URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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PURPOSE: We evaluated the difference in the febrile urinary tract infection rate in small children with dilating vesicoureteral reflux randomly allocated to 3 management alternatives, including antibiotic prophylaxis, endoscopic treatment or surveillance only as the control. MATERIALS AND METHODS: At 23 centers a total of 203 children were included in the study, including 128 girls and 75 boys 1 to younger than 2 years. Vesicoureteral reflux grade III in 126 cases and IV in 77 was detected after a febrile urinary tract infection (194) after prenatal screening (9). Voiding cystourethrography and dimercapto-succinic acid scintigraphy were done before randomization and after 2 years. The febrile urinary tract infection rate was analyzed by the intent to treat principle. RESULTS: We noted a total of 67 febrile recurrences in 42 girls and a total of 8 in 7 boys (p = 0.0001). There was a difference in the recurrence rate among treatment groups in girls with febrile infection in 8 of 43 (19%) on prophylaxis, 10 of 43 (23%) with endoscopic therapy and 24 of 42 (57%) on surveillance (p = 0.0002). In girls the recurrence rate was associated with persistent reflux after 2 years (p = 0.0095). However, reflux severity (grade III or IV) at study entry did not predict recurrence. CONCLUSIONS: In this randomized, controlled trial there was a high rate of recurrent febrile urinary tract infection in girls older than 1 year with dilating vesicoureteral reflux at study entry but not in boys. Antibiotic prophylaxis and endoscopic treatment decreased the infection rate.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Esbjörner, Elisabeth
(författare)
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Herthelius, MariaKarolinska Institutet
(författare)
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Swerkersson, Svante,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xswesv
(författare)
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Jodal, Ulf,1938Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xjodul
(författare)
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Hansson, Sverker,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xhansv
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Journal of urology: Ovid Technologies (Wolters Kluwer Health)184:1, s. 286-2911527-37920022-5347
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