Sökning: onr:"swepub:oai:gup.ub.gu.se/122850" >
Vincristine pharmac...
Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia.
-
- Lönnerholm, Gudmar (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer,Lönnerholm, G., Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden, Department of Women's and Children's Health, University Children's Hospital, SE-751 85 Uppsala, Sweden
-
- Frost, Britt-Marie (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer,Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden
-
- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Queen Silvia Children´s, Hospital, Gothenburg, Sweden
-
visa fler...
-
- Behrendtz, Mikael (författare)
- Östergötlands Läns Landsting,Barn- och ungdomskliniken i Linköping
-
- Castor, Anders (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Paediatrics, University Hospital, Lund, Sweden
-
- Forestier, Erik (författare)
- Umeå universitet,Pediatrik,Department of Clinical Sciences, Paediatrics, University of Umeå, Umeå, Sweden
-
- Heyman, Mats (författare)
- Karolinska Institutet,Childhood Cancer Research Unit, Karolinska University Hospital, Stockholm, Sweden
-
- Uges, Donald R A (författare)
- Department of Pharmacy, University Hospital, Groningen, Netherlands
-
- de Graaf, Siebold S N (författare)
- De Graaf, S.S.N., Department of Pediatrics, University Medical Centre St. Radboud, Nijmegen, Netherlands
-
visa färre...
-
(creator_code:org_t)
- 2008-06-04
- 2008
- Engelska.
-
Ingår i: British journal of haematology. - : Wiley. - 1365-2141 .- 0007-1048. ; 142:4, s. 616-21
- Relaterad länk:
-
https://onlinelibrar...
-
visa fler...
-
http://dx.doi.org/10...
-
http://www.ncbi.nlm....
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Vincristine is a key drug in the treatment of childhood and adult acute lymphoblastic leukemia (ALL), and many other childhood malignancies. Despite decades of wide clinical use, no data on the correlation between vincristine pharmacokinetics and long-term clinical outcome have been published. We here report clinical data (median follow-up time 10.5 years, range 7.3-12 years) for 86 children with B-cell precursor ALL, in whom vincristine kinetics were studied on treatment day 1. The median total plasma clearance was 429 and 331 ml/min per m(2) and the area under the plasma concentration-time curve (AUC) was 4.49 and 5.40 mg/l x min in relapse and non-relapse patients, respectively (not significant). In standard risk patients, where treatment depends more heavily on vincristine than in other subgroups, the relative risk (RR) of relapse was significantly increased for patients with clearance values above median (RR 5.2; P = 0.036), or AUC values below median (RR 5.8; P = 0.025). Our data suggest a relationship between the antileukemic effect and the systemic exposure of the drug, which warrants further studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Antineoplastic Agents
- Phytogenic
- pharmacokinetics
- therapeutic use
- Child
- Chromatography
- High Pressure Liquid
- Female
- Humans
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- blood
- drug therapy
- Treatment Outcome
- Vincristine
- administration & dosage
- blood
- pharmacokinetics
- drug effect
- vincristine
- acute lymphoblastic leukemia
- childhood
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas