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Clozapine: agonisti...
Clozapine: agonistic and antagonistic salivary secretory actions.
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- Ekström, Jörgen, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Godoy, Tania (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Riva, A (författare)
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(creator_code:org_t)
- 2010-01-21
- 2010
- Engelska.
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Ingår i: Journal of dental research. - : SAGE Publications. - 1544-0591 .- 0022-0345. ; 89:3, s. 276-80
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Individuals receiving clozapine treatment for schizophrenia complain of drooling. Reports on salivary flow measurements are contradictory in humans and lacking in animals. Clozapine has affinity for several different receptor types and may, hypothetically, both stimulate and inhibit salivary secretion. In rats, intravenous clozapine evoked a long-lasting secretion, being more prominent from submandibular than from parotid glands. Chronic denervation enhanced the responses. Clozapine acted on muscarinic (M1-) receptors of acinar cells, independent of central nervous mechanisms, pre-synaptic intraglandular events, or circulating catecholamines. A fraction of the methacholine- and parasympathetic-nerve-evoked secretion was abolished by clozapine at doses below those evoking secretion. Sympathetic-nerve-evoked secretion was partially reduced by clozapine, due to antagonistic action on alpha-adrenoceptors; the beta-adrenoceptor-mediated response persisted. Subsecretory doses of clozapine enhanced secretion induced by the beta-adrenoceptor agonist isoprenaline. The overall actions of clozapine suggest that, in clozapine-treated humans, salivation is increased during sleep and at rest, but is decreased during meals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Animals
- Antipsychotic Agents
- pharmacology
- Autonomic Denervation
- Cholinergic Agents
- pharmacology
- Clozapine
- pharmacology
- Disease Models
- Animal
- Dose-Response Relationship
- Drug
- Female
- Parotid Gland
- drug effects
- innervation
- secretion
- Rats
- Rats
- Sprague-Dawley
- Receptors
- Adrenergic
- beta
- drug effects
- Receptors
- Muscarinic
- drug effects
- Saliva
- secretion
- Salivation
- drug effects
- Sialorrhea
- chemically induced
- Submandibular Gland
- drug effects
- innervation
- secretion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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