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Cooperative trial C...
Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults.
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Dantonello, Tobias M (författare)
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Int-Veen, Christoph (författare)
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Harms, Dieter (författare)
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Leuschner, Ivo (författare)
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Schmidt, Bernhard F (författare)
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Herbst, Manfred (författare)
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Juergens, Heribert (författare)
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Scheel-Walter, Hans-Gerhard (författare)
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Bielack, Stefan S (författare)
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Klingebiel, Thomas (författare)
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Dickerhoff, Roswitha (författare)
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Kirsch, Sylvia (författare)
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Brecht, Ines (författare)
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Schmelzle, Rainer (författare)
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Greulich, Michael (författare)
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Gadner, Helmut (författare)
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Greiner, Jeanette (författare)
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- Marky, Ildiko, 1940 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Treuner, Joern (författare)
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Koscielniak, Ewa (författare)
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 27:9, s. 1446-55
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: To improve risk-adapted therapy for localized childhood soft tissue sarcoma within an international multicenter setting. PATIENTS AND METHODS: Four hundred forty-one patients younger than 21 years with localized rhabdomyosarcoma and rhabdomyosarcoma-like tumors (ie, extraosseous tumors of the Ewing family, synovial sarcoma, and undifferentiated sarcoma) were eligible. Therapy was stratified according to postsurgical stage, histology, and tumor site. In unresectable tumors, treatment was further adapted depending on response to induction chemotherapy, TN classification, tumor size and second-look surgery. A novel five-drug combination of etoposide, vincristine, dactinomycin, ifosfamide, and doxorubicin (EVAIA) was evaluated for high-risk patients, but cumulative chemotherapy dosage and treatment duration were reduced for the remaining individuals as compared with that of the previous trial CWS-86. Hyperfractionated accelerated radiotherapy (HART) was recommended at doses of either 32 or 48 Gy. RESULTS: At a median follow-up of 8 years, 5-year event-free survival (EFS) and overall (OS) survival for the entire cohort was 63% +/- 4% and 73% +/- 4%, respectively (all survival rates in this abstract are calculated and displayed with +/-95% CI). EFS/OS rates by histology were 60% +/- 5%/72% +/- 5% in rhabdomyosarcoma, 62% +/- 10%/69% +/- 10% for Ewing tumors of soft tissues, 84% +/- 12%/90% +/- 10% for synovial sarcoma, and 67% +/- 38%/83% +/- 30% for undifferentiated sarcoma, respectively. Response to one cycle of the five-drug combination EVAIA was similar to that of the four-drug combination VAIA used in CWS-86. Two hundred twelve patients with rhabdomyosarcoma underwent radiation (EFS, 66% +/- 6%); 53 of those patients had a favorable risk profile and received 32 Gy of HART (EFS, 73% +/- 12%). TN classification, tumor site, tumor size, histology, and age were prognostic in univariate analysis. CONCLUSION: Improved risk stratification enabled decreased therapy intensity for selected patients without compromising survival. Intensified chemotherapy with EVAIA did not improve outcome of localized high-risk rhabdomyosarcoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
- therapeutic use
- Child
- Child
- Preschool
- Combined Modality Therapy
- Dactinomycin
- administration & dosage
- Dose Fractionation
- Doxorubicin
- administration & dosage
- Etoposide
- administration & dosage
- Female
- Humans
- Ifosfamide
- administration & dosage
- Infant
- Infant
- Newborn
- Male
- Rhabdomyosarcoma
- therapy
- Sarcoma
- therapy
- Sarcoma
- Ewing's
- therapy
- Sarcoma
- Synovial
- therapy
- Soft Tissue Neoplasms
- therapy
- Vincristine
- administration & dosage
- Young Adult
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Dantonello, Tobi ...
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Int-Veen, Christ ...
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Harms, Dieter
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Leuschner, Ivo
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Schmidt, Bernhar ...
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Herbst, Manfred
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visa fler...
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Juergens, Heribe ...
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Scheel-Walter, H ...
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Bielack, Stefan ...
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Klingebiel, Thom ...
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Dickerhoff, Rosw ...
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Kirsch, Sylvia
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Brecht, Ines
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Schmelzle, Raine ...
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Greulich, Michae ...
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Gadner, Helmut
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Greiner, Jeanett ...
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Marky, Ildiko, 1 ...
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Treuner, Joern
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Koscielniak, Ewa
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Journal of clini ...
- Av lärosätet
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Göteborgs universitet