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Concomitant enterot...
Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh.
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Chowdhury, Fahima (författare)
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Begum, Yasmin A (författare)
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Alam, Mohammad Murshid (författare)
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Khan, Ashraful I (författare)
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Ahmed, Tanvir (författare)
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Bhuiyan, M Saruar (författare)
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Harris, Jason B (författare)
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LaRocque, Regina C (författare)
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Faruque, Abu S G (författare)
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Endtz, Hubert (författare)
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Ryan, Edward T (författare)
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Cravioto, Alejandro (författare)
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- Svennerholm, Ann-Mari, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Calderwood, Stephen B (författare)
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Qadri, Firdausi (författare)
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Infection and immunity. - 1098-5522. ; 78:5, s. 2117-24
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) are major bacterial pathogens that cause dehydrating disease requiring hospitalization of children and adults. The cholera toxin (CT) produced by V. cholerae O1 and the heat-labile toxin (LT) and/or heat-stable toxin (ST) of ETEC are responsible for secretory diarrhea. We have observed that about 13% of hospitalized diarrheal patients are concomitantly infected with V. cholerae O1 and ETEC. In order to understand the outcome of such dual infections on the clinical and immunological responses in cholera patients, we studied patients infected with V. cholerae O1 (group VC; n = 25), those infected with both V. cholerae O1 and ETEC (group VCET; n = 25), and those infected with ETEC only (group ET; n = 25). The VCET group showed more severe dehydration and had a higher intake of intravenous fluid and more vomiting than the ETEC group (P = 0.01 to 0.003). The VCET patients showed higher vibriocidal responses and increased antibody titers to cholera toxin and lipopolysaccharide (LPS) in plasma than did the V. cholerae O1 patients (P = 0.02 to <0.001). All responses in the V. cholerae O1 and in the VCET groups were more robust than those seen in the group infected with ETEC only (P = 0.01 to <0.001). We thus show that concomitant colonization with ETEC induces immune responses to V. cholerae antigens that are more robust than those seen with V. cholerae O1 infection alone. It is possible that LT or other factors expressed by ETEC may play a role as a mucosal adjuvant in enhancing the immune responses to V. cholerae O1.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Antibodies
- Bacterial
- blood
- Antigens
- Bacterial
- immunology
- Bangladesh
- Child
- Child
- Preschool
- Cholera
- complications
- immunology
- Enterotoxigenic Escherichia coli
- immunology
- Escherichia coli Infections
- complications
- immunology
- Female
- Humans
- Infant
- Male
- Vibrio cholerae O1
- immunology
- Young Adult
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Chowdhury, Fahim ...
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Begum, Yasmin A
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Alam, Mohammad M ...
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Khan, Ashraful I
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Ahmed, Tanvir
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Bhuiyan, M Sarua ...
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visa fler...
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Harris, Jason B
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LaRocque, Regina ...
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Faruque, Abu S G
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Endtz, Hubert
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Ryan, Edward T
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Cravioto, Alejan ...
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Svennerholm, Ann ...
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Calderwood, Step ...
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Qadri, Firdausi
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visa färre...
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Infection and im ...
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Göteborgs universitet