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Prophylactic Fibrin...
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Karlsson, Martin,1978Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
(författare)
Prophylactic Fibrinogen Infusion in Cardiac Surgery Patients: Effects on Biomarkers of Coagulation, Fibrinolysis, and Platelet Function.
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2010-06-07
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SAGE Publications,2011
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LIBRIS-ID:oai:gup.ub.gu.se/130374
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https://gup.ub.gu.se/publication/130374URI
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https://doi.org/10.1177/1076029610366437DOI
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Objective: We have recently reported that prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass grafting (CABG) surgery. Because fibrinogen for the first time was administered to patients without hereditary fibrinogen deficiency or ongoing bleeding, a detailed analysis of the effects of fibrinogen concentrate on biomarkers of coagulation, fibrinolysis, and platelet function was performed. Methods: Twenty CABG patients with preoperative plasma fibrinogen levels <3.8 g/L were included in a prospective study. Patients were randomized to preoperative infusion of 2 g fibrinogen concentrate (fibrinogen group) or no infusion (control group). Activated partial thromboplastin time (aPTT), prothrombin time, activated clotting time, and plasma concentrations of fibrinogen, antithrombin, thrombin-antithrombin complex, prothrombin fragment 1.2, and d-dimer, thromboelastometry, platelet count, and platelet aggregometry were analyzed before and 15 minutes after infusion, and 2 and 24 hours after surgery. Results: Fifteen minutes after infusion of fibrinogen concentrate, fibrinogen plasma levels increased by 0.6 +/- 0.2 g/L (P < .001 between groups), and induced minimal changes in aPTT and plasma levels of antithrombin, while remaining variables remained unchanged. After surgery, fibrinogen levels no longer differed between groups. d-dimer was significantly higher after surgery in the fibrinogen group (P = .03), while none of the other markers were statistically different between groups. Conclusions: Infusion of 2 g fibrinogen to cardiac surgery patients, without hereditary or acquired fibrinogen deficiency or ongoing bleeding, results in no or minimal changes in biomarkers reflecting coagulation and platelet function. An increased release of fibrin degradation products was detected after surgery in fibrinogen-treated patients.
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Ternström, Lisa,1972Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
(författare)
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Hyllner, Monica,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care(Swepub:gu)xhylmo
(författare)
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Baghaei, Fariba,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbagfa
(författare)
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Skrtic, Stanko,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk prövning och entreprenörskap,Institute of Medicine, Department of Clinical Trials and Entrepreneurship(Swepub:gu)xskrst
(författare)
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Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjepan
(författare)
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Göteborgs universitetInstitutionen för medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical and applied thrombosis/hemostasis: SAGE Publications17:4, s. 393-4041938-27231076-0296
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Karlsson, Martin ...
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Ternström, Lisa, ...
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Hyllner, Monica, ...
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Baghaei, Fariba, ...
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Skrtic, Stanko, ...
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Jeppsson, Anders ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Göteborgs universitet