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Prediction of drug-...
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Tjäderborn, Micaela
(författare)
Prediction of drug-related morphological changes of the T wave.
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-04-29
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Informa UK Limited,2010
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/130479
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https://gup.ub.gu.se/publication/130479URI
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https://doi.org/10.3109/14017431003789892DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVES: To describe the characteristics of patients presenting with morphological T wave changes that lead to measurement difficulties, and to identify possible predictors of such changes at baseline and early after start of treatment. DESIGN: ECGs from 145 patients receiving a combined potassium and sodium channel blocking agent for conversion of atrial fibrillation (AF), underwent semiautomatic analysis in a digitalized high-precision analysis program. In 15 patients, one or more ECGs were identified as difficult to interpret due to morphological T wave changes. They were compared with the 130 patients without such changes. RESULTS: A history of cardiac failure (p=0.027), a smaller left atrial area (p=0.010) and a longer QT(tang) minus QT(top) interval (p<0.001) at baseline was significantly more frequent as compared to the controls. Identified patients also had somewhat longer baseline QT interval duration (median QT(cB) 432 vs. 408 ms, N.S.) and a larger proportion of them were females (47% vs. 27%, N.S.). After start of infusion the QT(cB) became significantly longer in identified patients than in controls (p=0.012). CONCLUSIONS: Independent predictors of subsequent morphological changes were found at baseline and shortly after start of treatment, and may be of use to identify individuals with a reduced repolarization reserve.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
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Adult
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Aged
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Aged
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80 and over
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Anti-Arrhythmia Agents
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administration & dosage
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adverse effects
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Arrhythmias
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Cardiac
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chemically induced
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physiopathology
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Atrial Fibrillation
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drug therapy
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physiopathology
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Double-Blind Method
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Electrocardiogram Pattern
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Female
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Heart Conduction System
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drug effects
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physiopathology
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Humans
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Infusions
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Parenteral
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Logistic Models
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Male
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Middle Aged
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Organic Chemicals
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administration & dosage
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adverse effects
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Potassium Channel Blockers
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administration & dosage
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adverse effects
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Predictive Value of Tests
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Risk Assessment
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Risk Factors
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Sodium Channel Blockers
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administration & dosage
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adverse effects
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Sweden
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Time Factors
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Treatment Outcome
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Young Adult
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Aunes-Jansson, Maria
(författare)
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Samuelsson, Emma
(författare)
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Frison, Lars
(författare)
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Johansson, S
(författare)
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Berggren, Anders
(författare)
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Edvardsson, Nils,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xedvni
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian cardiovascular journal : SCJ: Informa UK Limited44:4, s. 215-221651-20061401-7431
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