Sökning: onr:"swepub:oai:gup.ub.gu.se/130910" > Inherited genetic v...
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001 | oai:gup.ub.gu.se/130910 | |
003 | SwePub | |
008 | 240528s2010 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-32699 | |
009 | oai:prod.swepub.kib.ki.se:120011220 | |
024 | 7 | a https://gup.ub.gu.se/publication/1309102 URI |
024 | 7 | a https://doi.org/10.1073/pnas.09140611072 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-326992 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1200112202 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Xu, Jianfeng4 aut |
245 | 1 0 | a Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. |
264 | c 2010-01-11 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2010 |
520 | a Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is urgently needed to reduce overdiagnosis and overtreatment of this common disease. To search for such factors, we compared the frequencies of SNPs among PCa patients who were defined as having either more aggressive or less aggressive disease in four populations examined in the Genetic Markers of Susceptibility (CGEMS) study performed by the National Cancer Institute. SNPs showing possible associations with disease severity were further evaluated in an additional three independent study populations from the United States and Sweden. In total, we studied 4,829 and 12,205 patients with more and less aggressive disease, respectively. We found that the frequency of the TT genotype of SNP rs4054823 at 17p12 was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied, with an overall P value of 2.1 x 10(-8) under a recessive model, exceeding the conservative genome-wide significance level. The difference in frequency was largest between patients with high-grade, non-organ-confined disease compared with those with low-grade, organ-confined disease. This study demonstrates that inherited variants predisposing to aggressive but not indolent PCa exist in the genome, and suggests that the clinical potential of such variants as potential early markers for risk of aggressive PCa should be evaluated. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a Gene Frequency | |
653 | a Genetic Predisposition to Disease | |
653 | a Genetic Variation | |
653 | a Genotype | |
653 | a Humans | |
653 | a Male | |
653 | a Neoplasm Invasiveness | |
653 | a genetics | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Prostatic Neoplasms | |
653 | a genetics | |
653 | a pathology | |
653 | a Registries | |
653 | a Sweden | |
653 | a Tumor Markers | |
653 | a Biological | |
653 | a genetics | |
653 | a United States | |
653 | a MEDICINE | |
700 | 1 | a Zheng, Siqun Lilly4 aut |
700 | 1 | a Isaacs, Sarah D4 aut |
700 | 1 | a Wiley, Kathleen E4 aut |
700 | 1 | a Wiklund, Fredriku Karolinska Institutet4 aut |
700 | 1 | a Sun, Jielin4 aut |
700 | 1 | a Kader, A Karim4 aut |
700 | 1 | a Li, Ge4 aut |
700 | 1 | a Purcell, Lina D4 aut |
700 | 1 | a Kim, Seong-Tae4 aut |
700 | 1 | a Hsu, Fang-Chi4 aut |
700 | 1 | a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003 |
700 | 1 | a Hugosson, Jonas,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology4 aut0 (Swepub:gu)xhugjo |
700 | 1 | a Adolfsson, Janu Karolinska Institutet4 aut |
700 | 1 | a Walsh, Patrick C4 aut |
700 | 1 | a Trent, Jeffrey M4 aut |
700 | 1 | a Duggan, David4 aut |
700 | 1 | a Carpten, John4 aut |
700 | 1 | a Grönberg, Henriku Karolinska Institutet4 aut |
700 | 1 | a Isaacs, William B4 aut |
710 | 2 | a Karolinska Institutetb Urologi och andrologi4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 107:5, s. 2136-40q 107:5<2136-40x 1091-6490x 0027-8424 |
773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 107:5, s. 2136-40q 107:5<2136-40x 0027-8424 |
856 | 4 | u https://europepmc.org/articles/pmc2836698?pdf=render |
856 | 4 8 | u https://gup.ub.gu.se/publication/130910 |
856 | 4 8 | u https://doi.org/10.1073/pnas.0914061107 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32699 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120011220 |
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