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In-treatment reduce...
In-treatment reduced left atrial diameter during antihypertensive treatment is associated with reduced new-onset atrial fibrillation in hypertensive patients with left ventricular hypertrophy: The LIFE Study
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Wachtell, K. (författare)
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Gerdts, E. (författare)
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Aurigemma, G. P. (författare)
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visa fler...
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Boman, K. (författare)
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- Dahlöf, Björn, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine
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Nieminen, M. S. (författare)
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Olsen, M. H. (författare)
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Okin, P. M. (författare)
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Palmieri, V. (författare)
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Rokkedal, J. E. (författare)
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Devereux, R. B. (författare)
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visa färre...
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Blood Pressure. - 0803-7051. ; 19:3, s. 169-175
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- OBJECTIVE: It is unclear whether improvement of left atrial (LA) and ventricular (LV) structure results in reduction in new-onset atrial fibrillation (AF). The aim of the present study was to examine whether changes in-treatment LA diameter were related to changes in risk of new-onset AF. METHODS: We followed 939 hypertensive patients with electrocardiographic LV hypertrophy randomized to atenolol or losartan-based regimens in the LIFE Study for a mean of 4.8 years with echocardiograms at enrolment and annually during treatment. RESULTS: New-onset AF occurred in 46 patients (10.2/1000 patient-years of follow-up). At baseline, patients with new-onset AF were older, had higher systolic blood pressure and heart rate as well as higher prevalence of LA dilatation, but had similar prevalences of LV hypertrophy and mitral or aortic valve disease. In univariate Cox analysis baseline LA diameter (HR=4.67 per cm increase [95% CI 2.86-7.65], p<0.001) and LV mass index (HR=1.11 per 10 g/m(2) increase [95% CI 1.02-1.22], p<0.05) both predicted new-onset AF. In multivariate analysis, increased baseline LA diameter increased the risk of new-onset AF (HR=5.16 per cm [95% CI 2.85-9.35], p<0.001) whereas reduction of in-treatment LA diameter reduced the risk (HR=0.21 per cm lower LA diameter during treatment [95% CI 0.14-0.32], p<0.001) with adjustment for in-treatment LV mass in-treatment systolic blood pressure, age and Framingham risk score. CONCLUSION: LA diameter at baseline and during antihypertensive treatment were equally strong predictors of new-onset AF independent of the level of arterial pressure, LV mass and other covariates. Prevention of AF during antihypertensive treatment may be improved by antihypertensive therapy that reduces LA size in addition to controlling blood pressure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aged
- Antihypertensive Agents/pharmacology/*therapeutic use
- Arrhythmias
- Cardiac/complications/drug therapy
- Atenolol/pharmacology/therapeutic use
- Atrial Fibrillation/drug therapy/epidemiology/*prevention & control
- Blood Pressure/drug effects
- Cardiomegaly/complications/drug therapy
- Cardiovascular Diseases/complications/drug therapy
- Electrocardiography
- Female
- Heart Atria/physiopathology
- Heart Rate
- Heart Ventricles/physiopathology
- Humans
- Hypertension/complications/*drug therapy/physiopathology
- Hypertrophy
- Left Ventricular/complications/*drug therapy/*physiopathology
- Losartan/pharmacology/therapeutic use
- Male
- Middle Aged
- Risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Wachtell, K.
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Gerdts, E.
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Aurigemma, G. P.
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Boman, K.
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Dahlöf, Björn, 1 ...
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Nieminen, M. S.
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visa fler...
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Olsen, M. H.
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Okin, P. M.
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Palmieri, V.
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Rokkedal, J. E.
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Devereux, R. B.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Blood Pressure
- Av lärosätet
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Göteborgs universitet