Sökning: onr:"swepub:oai:gup.ub.gu.se/132597" > Gram-positive and g...
Fältnamn | Indikatorer | Metadata |
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000 | 06578naa a2200853 4500 | |
001 | oai:gup.ub.gu.se/132597 | |
003 | SwePub | |
008 | 240528s2010 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-9722 | |
024 | 7 | a https://gup.ub.gu.se/publication/1325972 URI |
024 | 7 | a https://doi.org/10.1089/jir.2009.00332 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97222 URI |
040 | a (SwePub)gud (SwePub)oru | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Skovbjerg, Susann,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Inst Biomed, Dept Infect Med Clin Bacteriol,Univ Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xjsusm |
245 | 1 0 | a Gram-positive and gram-negative bacteria induce different patterns of cytokine production in human mononuclear cells irrespective of taxonomic relatedness. |
264 | 1 | a New York, USA :b Mary Ann Liebert Inc,c 2010 |
520 | a Upon bacterial stimulation, tissue macrophages produce a variety of cytokines that orchestrate the immune response that clears the infection. We have shown that Gram-positives induce higher levels of interleukin-12 (IL-12), interferon-gamma (IFN-gamma), and tumor necrosis factor (TNF) from human peripheral blood mononuclear cells (PBMCs) than do Gram-negatives, which instead induce more of IL-6, IL-8, and IL-10. Here, we study whether these patterns follows or crosses taxonomic borders. PBMCs from blood donors were incubated with UV-inactivated bacteria representing 37 species from five phyla. IL-12, TNF, IL-1beta, IL-6, IL-8, and IL-10 were measured in the supernatants after 24 h and IFN-gamma after 5 days. Irrespective of phylogenetic position, Gram-positive bacteria induced much more IL-12 (nine times more on average) and IFN-gamma (seven times), more TNF (three times), and slightly more IL-1beta (1.5 times) than did Gram-negatives, which instead induced more IL-6 (1.5 times), IL-8 (1.9 times), and IL-10 (3.3 times) than did Gram-positives. A notable exception was the Gram-positive Listeria monocytogenes, which induced very little IL-12, IFN-gamma, and TNF. The results confirm the fundamental difference in innate immune responses to Gram-positive and Gram-negative bacteria, which crosses taxonomic borders and probably reflects differences in cell wall structure. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
653 | a Antigens | |
653 | a Bacterial | |
653 | a immunology | |
653 | a Cells | |
653 | a Cultured | |
653 | a Cytokines | |
653 | a metabolism | |
653 | a Enzyme-Linked Immunosorbent Assay | |
653 | a Gram-Negative Bacteria | |
653 | a immunology | |
653 | a Gram-Positive Bacteria | |
653 | a immunology | |
653 | a Humans | |
653 | a Immunity | |
653 | a Innate | |
653 | a Inflammation Mediators | |
653 | a metabolism | |
653 | a Leukocytes | |
653 | a Mononuclear | |
653 | a immunology | |
653 | a metabolism | |
653 | a microbiology | |
653 | a pathology | |
653 | a Lymphocyte Activation | |
653 | a Phagocytosis | |
653 | a immunology | |
653 | a Species Specificity | |
653 | a Ultraviolet Rays | |
653 | a Culinary Arts and Meal Science | |
653 | a Måltidskunskap | |
700 | 1 | a Martner, Anna,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Inst Biomed, Dept Infect Med Clin Bacteriol, Univ Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xbigan |
700 | 1 | a Hynsjö, Larsu Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Inst Biomed, Dept Clin Chem & Transfus Med, Univ Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xhynla |
700 | 1 | a Hessle, Christina,d 1965u Inst Biomed, Dept Infect Med Clin Bacteriol, Univ Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xhesch |
700 | 1 | a Olsen, Ingaru Inst Oral Biol, Fac Dent, Univ Oslo, Oslo, Norway4 aut |
700 | 1 | a Dewhirst, Floyd Eu Sch Dent Med, Harvard Univ, Boston MA, USA4 aut |
700 | 1 | a Tham, Wilhelmu Örebro universitet,Restaurang- och hotellhögskolan - Grythytte akademi4 aut0 (Swepub:oru)wtm |
700 | 1 | a Wold, Agnes E,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Inst Biomed, Dept Infect Med Clin Bacteriol, Univ Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xwolag |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org |
773 | 0 | t Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Researchd New York, USA : Mary Ann Liebert Incg 30:1, s. 23-32q 30:1<23-32x 1557-7465x 1079-9907 |
773 | 0 | t Journal of Interferon & Cytokine Researchd New York, USA : Mary Ann Liebert Incg 30:1, s. 23-32q 30:1<23-32x 1079-9907 |
856 | 4 8 | u https://gup.ub.gu.se/publication/132597 |
856 | 4 8 | u https://doi.org/10.1089/jir.2009.0033 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-9722 |
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