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Ablation of the ver...
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity.
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- Zadravec, Damir, 1980- (författare)
- Stockholms universitet,Wenner-Grens institut
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- Brolinson, Annelie (författare)
- Stockholms universitet,Wenner-Grens institut
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- Fisher, Rachel M (författare)
- Karolinska Institutet
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- Carneheim, Claes (författare)
- Stockholms universitet,Wenner-Grens institut
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- Csikasz, Robert (författare)
- Stockholms universitet,Wenner-Grens institut
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Bertrand-Michel, Justine (författare)
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- Borén, Jan, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Guillou, Hervé (författare)
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- Rudling, Mats (författare)
- Karolinska Institutet
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- Jacobsson, Anders (författare)
- Stockholms universitet,Wenner-Grens institut
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(creator_code:org_t)
- 2010-07-06
- 2010
- Engelska.
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Ingår i: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860 .- 0892-6638. ; 24:11, s. 4366-77
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Abstract
Ämnesord
Stäng
- Although saturated and monounsaturated very-long-chain fatty acids (VLCFAs) have long been associated with undesirable effects on health, including obesity, heart failure, and atherosclerosis, the physiological role of endogenous synthesis is largely unknown. The fatty acid elongase ELOVL3 is involved in the synthesis of C20-C24 saturated and monounsaturated VLCFAs mainly in liver, brown and white adipose tissue, and triglyceride-rich glands such as the sebaceous and meibomian glands. Here we show that ablation of ELOVL3 leads to reduced adiponectin levels, constrained expansion of adipose tissue, and resistance against diet-induced obesity, a situation that is more exaggerated in female mice. Both female and male knockout mice show reduced hepatic lipogenic gene expression and triglyceride content, a situation that is associated with reduced de novo fatty acid synthesis and uptake. As a consequence, the VLDL-triglyceride level in serum is significantly reduced. Remarkably, despite increased energy expenditure, markedly reduced serum levels of leptin, and increased expression of orexigenic peptides in the hypothalamus, the Elovl3(-/-) mice do not compensate by increased food intake. Thus, these results reveal that C20-C22 saturated and monounsaturated VLCFAs produced by ELOVL3 are indispensable for appropriate synthesis of liver triglycerides, fatty acid uptake, and storage in adipose tissue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Nyckelord
- Acetyltransferases
- genetics
- metabolism
- Adipokines
- secretion
- Adiponectin
- blood
- Adipose Tissue
- metabolism
- Animals
- Basal Metabolism
- genetics
- Cells
- Cultured
- Diet
- Eating
- genetics
- Female
- Gene Expression Regulation
- Enzymologic
- Lipogenesis
- genetics
- Lipoproteins
- VLDL
- biosynthesis
- blood
- Liver
- metabolism
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Obesity
- enzymology
- metabolism
- Sex Factors
- Triglycerides
- biosynthesis
- blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Zadravec, Damir, ...
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Brolinson, Annel ...
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Fisher, Rachel M
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Carneheim, Claes
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Csikasz, Robert
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Bertrand-Michel, ...
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visa fler...
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Borén, Jan, 1963
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Guillou, Hervé
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Rudling, Mats
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Jacobsson, Ander ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Zoologi
- Artiklar i publikationen
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The FASEB journa ...
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The FASEB Journa ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet
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Stockholms universitet