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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03356naa a2200481 4500 | |
| 001 | oai:gup.ub.gu.se/139993 | |
| 003 | SwePub | |
| 008 | 240528s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1399932 URI |
| 024 | 7 | a https://doi.org/10.1210/er.2009-00392 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Hochberg, Z.4 aut |
| 245 | 1 0 | a Child health, developmental plasticity, and epigenetic programming |
| 264 | c 2010-10-22 | |
| 264 | 1 | b The Endocrine Society,c 2011 |
| 520 | a Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs. | |
| 700 | 1 | a Feil, R.4 aut |
| 700 | 1 | a Constancia, M.4 aut |
| 700 | 1 | a Fraga, M.4 aut |
| 700 | 1 | a Junien, C.4 aut |
| 700 | 1 | a Carel, J. C.4 aut |
| 700 | 1 | a Boileau, P.4 aut |
| 700 | 1 | a Le Bouc, Y.4 aut |
| 700 | 1 | a Deal, C. L.4 aut |
| 700 | 1 | a Lillycrop, K.4 aut |
| 700 | 1 | a Scharfmann, R.4 aut |
| 700 | 1 | a Sheppard, A.4 aut |
| 700 | 1 | a Skinner, M.4 aut |
| 700 | 1 | a Szyf, M.4 aut |
| 700 | 1 | a Waterland, R. A.4 aut |
| 700 | 1 | a Waxman, D. J.4 aut |
| 700 | 1 | a Whitelaw, E.4 aut |
| 700 | 1 | a Ong, K.4 aut |
| 700 | 1 | a Albertsson-Wikland, Kerstin,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xalbke |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org |
| 773 | 0 | t Endocrine reviewsd : The Endocrine Societyg 32:2, s. 159-224q 32:2<159-224x 0163-769Xx 1945-7189 |
| 856 | 4 | u https://academic.oup.com/edrv/article-pdf/32/2/159/8858124/edrv0159.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/139993 |
| 856 | 4 8 | u https://doi.org/10.1210/er.2009-0039 |
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