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A ceramic drug deli...
A ceramic drug delivery vehicle for oral administration of highly potent opioids.
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- Forsgren, Johan (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Jämstorp, Erik (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Bredenberg, Susanne (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Engqvist, Håkan (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Tillämpad materialvetenskap
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- Strømme, Maria (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Journal of pharmaceutical sciences. - : Elsevier BV. - 1520-6017 .- 0022-3549. ; 99:1, s. 219-26
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Pellets composed of the ceramic material Halloysite and microcrystalline cellulose were synthesized with the aim of producing a drug delivery vehicle for sustained release of the opioid Fentanyl with low risk for dose dumping at oral intake of the highly potent drug. Drug release profiles of intact and crushed pellets, to simulate swallowing without or with chewing, in pH 6.8, pH 1, and in 48% ethanol were recorded in order to replicate the conditions in the small intestines, in the stomach, as well as cointake of the drug with alcohol. The drug release was analyzed by employing the Weibull equation, which showed that the release profiles were either governed by fickian diffusion (intact pellets in pH 6.8 and in ethanol) or by diffusion in a fractal or disordered pore network (intact pellets in pH 1 and crushed pellets in all solutions). A sustained release for approximately 3-4 h was obtained in all studied solutions from intact pellets, whereas crushed pellets released the drug content during approximately 2-3 h. The finding that a sustained release profile could be obtained both in alcohol and after crushing of the pellets, shows that the ceramic carrier under investigation, at least to some extent, hampers dose dumping, and may thus be a promising material in future developments of new opioid containing oral dosage forms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Annan materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Other Materials Engineering (hsv//eng)
Nyckelord
- Administration
- Oral
- Aluminum Silicates
- chemistry
- Analgesics
- Opioid
- administration & dosage
- chemistry
- pharmacokinetics
- Delayed-Action Preparations
- Drug Carriers
- chemistry
- Drug Compounding
- Fentanyl
- administration & dosage
- chemistry
- pharmacokinetics
- Hydrogen-Ion Concentration
- Microscopy
- Electron
- Scanning
- Particle Size
- Powders
- Solubility
- Surface Properties
- Functional materials
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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