Sökning: onr:"swepub:oai:gup.ub.gu.se/147462" > Systemic inflammati...
Fältnamn | Indikatorer | Metadata |
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000 | 03942naa a2200433 4500 | |
001 | oai:gup.ub.gu.se/147462 | |
003 | SwePub | |
008 | 240528s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1474622 URI |
024 | 7 | a https://doi.org/10.1002/ana.224892 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Favrais, Géraldine4 aut |
245 | 1 0 | a Systemic inflammation disrupts the developmental program of white matter. |
264 | c 2011-07-27 | |
264 | 1 | b Wiley,c 2011 |
520 | a OBJECTIVE: Perinatal inflammation is a major risk factor for neurological deficits in preterm infants. Several experimental studies have shown that systemic inflammation can alter the programming of the developing brain. However, these studies do not offer detailed pathophysiological mechanisms, and they rely on relatively severe infectious or inflammatory stimuli that most likely do not reflect the levels of systemic inflammation observed in many human preterm infants. The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development. METHODS: Newborn mice received twice-daily intraperitoneal injections of interleukin-1β (IL-1β) over 5 days and were studied for myelination, oligodendrogenesis, and behavior and with magnetic resonance imaging (MRI). RESULTS: Mice exposed to IL-1β had a long-lasting myelination defect that was characterized by an increased number of nonmyelinated axons. They also displayed a reduction of the diameter of the myelinated axons. In addition, IL-1β induced a significant reduction of the density of myelinating oligodendrocytes accompanied by an increased density of oligodendrocyte progenitors, suggesting a partial blockade in the oligodendrocyte maturation process. Accordingly, IL-1β disrupted the coordinated expression of several transcription factors known to control oligodendrocyte maturation. These cellular and molecular abnormalities were correlated with a reduced white matter fractional anisotropy on diffusion tensor imaging and with memory deficits. INTERPRETATION: Moderate perinatal systemic inflammation alters the developmental program of the white matter. This insult induces a long-lasting myelination deficit accompanied by cognitive defects and MRI abnormalities, further supporting the clinical relevance of the present data. ANN NEUROL 2011. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
700 | 1 | a van de Looij, Yohan4 aut |
700 | 1 | a Fleiss, Bobbiu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xflebo |
700 | 1 | a Ramanantsoa, Nelina4 aut |
700 | 1 | a Bonnin, Philippe4 aut |
700 | 1 | a Stoltenburg-Didinger, Gisela4 aut |
700 | 1 | a Lacaud, Adrien4 aut |
700 | 1 | a Saliba, Elie4 aut |
700 | 1 | a Dammann, Olaf4 aut |
700 | 1 | a Gallego, Jorge4 aut |
700 | 1 | a Sizonenko, Stéphane4 aut |
700 | 1 | a Hagberg, Henrik,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xhaghe |
700 | 1 | a Lelièvre, Vincent4 aut |
700 | 1 | a Gressens, Pierre4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
773 | 0 | t Annals of neurologyd : Wileyg 70:4, s. 550-565q 70:4<550-565x 1531-8249x 0364-5134 |
856 | 4 8 | u https://gup.ub.gu.se/publication/147462 |
856 | 4 8 | u https://doi.org/10.1002/ana.22489 |
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