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Bisphosphonate coat...
Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks.
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- Wermelin, Karin, 1977- (författare)
- Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet
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- Aspenberg, Per (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken Linköping
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- Linderbäck Stenfors, Paula (författare)
- Linköpings universitet,Institutionen för fysik, kemi och biologi,Tekniska högskolan
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- Tengvall, Pentti (författare)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Tillämpad Fysik,Tekniska högskolan
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Journal of biomedical materials research. Part A. - Hoboken, NJ, United States : Wiley. - 1552-4965 .- 1549-3296. ; 86:1, s. 220-7
- Relaterad länk:
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http://urn.kb.se/res...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Recently published data indicate that immobilized N-bisphosphonate enhances the pullout force and energy uptake of implanted stainless steel screws at 2 weeks in rat tibia. This study compares titanium screws with and without a bisphosphonate coating in the same animal model. The screws were first coated with an approximately 100-nm thick crosslinked fibrinogen film. Pamidronate was subsequently immobilized into this film via EDC/NHS-activated carboxyl groups within the fibrinogen matrix, and finally another N-bisphosphonate, ibandronate, was physically adsorbed. The release kinetics of immobilized (14)C-alendronate was measured in buffer up to 724 h and showed a 60% release within 8 h. Mechanical tests demonstrated a 32% (p = 0.04) and 48% (p = 0.02) larger pullout force and energy until failure after 2 weeks of implantation, compared to uncoated titanium screws. A control study with physically adsorbed pamidronate showed no effect on mechanical fixation, probably due to a too small adsorbed amount. We conclude that the fixation of titanium implants in bone can be improved by fibrinogen matrix-bound bisphosphonates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Adsorption
- Animals
- Coated Materials
- Biocompatible
- Diphosphonates
- chemistry
- Fibrinogen
- chemistry
- Gamma Rays
- Internal Fixators
- Male
- Materials Testing
- Rats
- Rats
- Sprague-Dawley
- Stainless Steel
- Stress
- Mechanical
- Tibia
- pathology
- Titanium
- chemistry
- Bisphosphonate
- Orthopaedics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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