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Solid-Phase Synthes...
Solid-Phase Synthesis of 5 '-O- N-(Acyl)sulfamoyl adenosine Derivatives
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- Redwan, Itedale Namro, 1981 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Jacobson Ingemyr, Hanna (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Ljungdahl, Thomas, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lawson, Christopher, 1968 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Grøtli, Morten, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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(creator_code:org_t)
- 2012-05-16
- 2012
- Engelska.
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Ingår i: European Journal of Organic Chemistry. - : Wiley. - 1434-193X .- 1099-0690. ; 2012:19, s. 3665-3669
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The solid-phase synthesis of 5'-O-[N-(acyl)sulfamoyl]adenosine derivatives is described. The use of a Rink amide polystyrene solid support together with an appropriately protected ribo-purine starting material allowed for the development of a highly reliable and practical route for the solid-phase synthesis of 5'-O-[N-(acyl)sulfamoyl]adenosines. The developed procedure enables the efficient parallel synthesis of the target compounds in high yields. These compounds are non-hydrolysable isosteres of acyl-adenylates, which play an important role in a range of different metabolic pathways such as ribosomal and non-ribosomal peptide synthesis, fatty acid oxidation or enzyme regulation; some adenylate-forming enzymes are potential drug targets.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Farmaceutisk synteskemi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Pharmaceutical Chemistry (hsv//eng)
Nyckelord
- Medicinal chemistry
- Synthetic methods
- Solid-phase synthesis
- Enzymes
- Nucleosides
- transfer-rna synthetase
- mycobacterium-tuberculosis
- siderophore
- biosynthesis
- pantothenate synthetase
- analogs
- inhibitors
- adenylate
- acid
- antibiotics
- siderophore
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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