Sökning: onr:"swepub:oai:gup.ub.gu.se/160902" >
Long-term mortality...
Long-term mortality in patients with type 2 diabetes undergoing coronary angiography: the impact of glucose-lowering treatment
-
- Saleh, N. (författare)
- Karolinska Institutet
-
Petursson, Petur, 1973 (författare)
-
- Lagerqvist, Bo (författare)
- Uppsala universitet,Kardiologi
-
visa fler...
-
Skuladottir, H. (författare)
-
Svensson, A. (författare)
-
- Eliasson, Björn, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
-
- Gudbjörnsdottir, Soffia, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
-
- Eeg-Olofsson, Katarina, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
-
- Norhammar, A. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2012-05-08
- 2012
- Engelska.
-
Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 55:8, s. 2109-2117
- Relaterad länk:
-
https://link.springe...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The aim of this study was to analyse whether the increased mortality rates observed in insulin-treated patients with type 2 diabetes and coronary artery disease are explained by comorbidities and complications. A retrospective analysis of data from two Swedish registries of type 2 diabetic patients (n = 12,515) undergoing coronary angiography between the years 2001 and 2009 was conducted. The association between glucose-lowering treatment and long-term mortality was studied after extensive adjustment for cardiovascular- and diabetes-related confounders. Patients were classified into four groups, according to glucose-lowering treatment: diet alone; oral therapy alone; insulin in combination with oral therapy; and insulin alone. After a mean follow-up time of 4.14 years, absolute mortality rates for patients treated with diet alone, oral therapy alone, insulin in combination with oral therapy and insulin alone were 19.2%, 17.4%, 22.9% and 28.1%, respectively. Compared with diet alone, insulin in combination with oral therapy (HR 1.27; 95% CI 1.12, 1.43) and insulin alone (HR 1.62; 95% CI 1.44, 1.83) were associated with higher mortality rates. After adjustment for baseline differences, insulin in combination with oral glucose-lowering treatment (HR 1.22; 95% CI 1.06, 1.40; p < 0.005) and treatment with insulin only (HR 1.17; 95% CI 1.02, 1.35; p < 0.01) remained independent predictors for long-term mortality. Type 2 diabetes patients treated with insulin and undergoing coronary angiography have a higher long-term mortality risk after adjustment for measured confounders. Further research is needed to evaluate the optimal glucose-lowering treatment for these high-risk patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Coronary angiography
- Coronary artery disease
- Diabetes
- Insulin
- Mortality
- Treatment
- acute myocardial-infarction
- blood-glucose
- clinical-outcomes
- artery-disease
- mellitus
- trial
- association
- insulin
- hypoglycemia
- dysfunction
- Coronary angiography
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Saleh, N.
-
Petursson, Petur ...
-
Lagerqvist, Bo
-
Skuladottir, H.
-
Svensson, A.
-
Eliasson, Björn, ...
-
visa fler...
-
Gudbjörnsdottir, ...
-
Eeg-Olofsson, Ka ...
-
Norhammar, A.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Göteborgs universitet
-
Uppsala universitet
-
Karolinska Institutet