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The Impact of Chron...
The Impact of Chronic Obstructive Pulmonary Disease in Patients Hospitalized for Worsening Heart Failure With Reduced Ejection Fraction: An Analysis of the EVEREST Trial
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Mentz, R. J. (author)
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Schmidt, P. H. (author)
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Kwasny, M. J. (author)
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Ambrosy, A. P. (author)
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O'Connor, C. M. (author)
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Konstam, M. A. (author)
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Zannad, F. (author)
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Maggioni, A. P. (author)
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- Swedberg, Karl, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Gheorghiade, M. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Journal of Cardiac Failure. - : Elsevier BV. - 1071-9164. ; 18:7, s. 515-523
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Abstract
Subject headings
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- Background: Chronic obstructive pulmonary disease (COPD) is prevalent in heart failure (HF) patients, yet these patients are poorly characterized. We aimed to describe the characteristics and outcomes of patients with systolic dysfunction and COPD in a contemporary HF randomized trial. Methods and Results: EVEREST investigated 4,133 patients hospitalized with worsening HF and an ejection fraction (EF) <= 40%. We analyzed the characteristics and outcomes (all-cause mortality and cardiovascular mortality/HF hospitalization) of patients according to baseline COPD status. COPD was present in 10% (n = 416) of patients. Patients with COPD had a higher prevalence of comorbidities and were less likely to receive a beta-blocker, angiotensin-converting enzyme inhibitor, or aldosterone antagonist. On univariate analysis, COPD was associated with increased all-cause mortality (HR 1.41, 95% CI 1.18-1.67) and cardiovascular mortality/HF hospitalization (HR 1.29, 95% CI 1.11-1.49). After adjusting for potential confounders, the risk associated with COPD remained increased, but was not statistically significant. Conclusion: The presence of COPD in HF patients is associated with an increased burden of comorbidities, lower use of HF therapies, and a trend toward worse outcomes. These findings provide a starting point for prospective investigations of the treatment of HF comorbidities to reduce the high postdischarge event rates. CI Cardiac Fail 2012;18:515-523)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- COPD
- heart failure
- hospitalization
- outcomes
- beta-adrenoceptor agonists
- quality-of-care
- vasopressin antagonism
- systolic dysfunction
- tolvaptan everest
- elderly-patients
- optimize-hf
- mortality
- diagnosis
- survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mentz, R. J.
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Schmidt, P. H.
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Kwasny, M. J.
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Ambrosy, A. P.
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O'Connor, C. M.
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Konstam, M. A.
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show more...
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Zannad, F.
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Maggioni, A. P.
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Swedberg, Karl, ...
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Gheorghiade, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Cardi ...
- By the university
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University of Gothenburg