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Comparison of the effects of different statins and doses on lipid levels in patients with diabetes: Results from VOYAGER

Karlson, Björn W., 1953 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
Barter, P. J. (författare)
Palmer, M. K. (författare)
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Lundman, P. (författare)
Karolinska Institutet
Nicholls, S. J. (författare)
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 (creator_code:org_t)
Elsevier BV, 2012
2012
Engelska.
Ingår i: Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 22:9, s. 697-703
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background and aims: Diabetes mellitus is a well-known risk factor for cardiovascular disease, and brings an increased risk of vascular events and a higher mortality rate. Treatment guidelines recommend statins in patients with diabetes, with low-density lipoprotein cholesterol (LDL-C) targets of 100 mg dl(-1) (similar to 2.5 mmol l(-1)), and 80 (similar to 2.0 mmol l(-1)) or 70 mg dl(-1) (similar to 1.8 mmol l(-1)) in especially high-risk patients. The current study used the VOYAGER (an indiVidual patient data-meta-analysis Of statin therapY in At risk Groups: Effects of Rosuvastatin, atorvastatin, and simvastatin) database to characterise effects of rosuvastatin, atorvastatin and simvastatin in different doses on lipid levels in diabetes patients. Methods and results: The VOYAGER database included individual patient data from 37 studies involving comparisons of rosuvastatin with either atorvastatin or simvastatin. Of the 32 258 patients included, 8859 (27.5%) had diabetes. Rosuvastatin appeared to be the most efficacious of the three statins, both for lowering LDL-C and for reaching a target level of <70 mg dl(-1) for LDL-C. It was also more effective than atorvastatin at raising high-density lipoprotein cholesterol in the diabetes population. These results are consistent with the overall VOYAGER results. Conclusions: This meta-analysis of 8859 patients with diabetes mellitus shows favourable effects on lipids with the three statins studied, in line with results for the overall VOYAGER population. The importance of using an effective statin at an effective dose to reach treatment goals for such high-risk patients is evident. (c) 2012 Elsevier B.V. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Atorvastatin
Diabetes mellitus
Cholesterol
LDL
Hydroxymethyl-glutaryl-CoA reductase inhibitors
placebo-controlled trial
coronary-heart-disease
treatment panel-iii
cardiovascular-disease
primary prevention
clinical-practice
cholesterol
rosuvastatin
atorvastatin
guidelines

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