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Efficacy of delayed...
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Eriksson, Bengt I.,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics
(författare)
Efficacy of delayed thromboprophylaxis with dabigatran: Pooled analysis.
- Artikel/kapitelEngelska2012
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LIBRIS-ID:oai:gup.ub.gu.se/166356
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https://gup.ub.gu.se/publication/166356URI
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https://doi.org/10.1016/j.thromres.2012.08.315DOI
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INTRODUCTION: Oral thromboprophylaxis with dabigatran etexilate should be initiated as a half dose 1 to 4h after major orthopaedic surgery. However, a delay in dosing could occur for clinical or logistical reasons. A post hoc analysis was carried out to determine if patients with delayed dosing received adequate anticoagulation. PATIENTS AND METHODS: The RE-MODEL™ and RE-NOVATE® trials compared 220mg and 150mg dabigatran etexilate with 40mg enoxaparin. Pooled data for major venous thromboembolism (VTE) and VTE-related mortality (efficacy outcome) and major bleeding events (MBE), MBE/clinically relevant bleeding events, and all bleeding events (safety outcomes) were analysed. Results in patients with dosing delayed more than 4h postsurgery were compared with those of patients without a delay. RESULTS: Onset of treatment was delayed in 724 (13.3%) of 5425 patients. Efficacy of 220mg dabigatran etexilate was similar in patients without delayed dosing, patients with a delay and patients with a delay until the day after surgery. Rates of efficacy outcome were higher in patients on 150mg dabigatran etexilate, but more than 80% of these patients were undertreated based on age or renal clearance status. Some differences in bleeding events were seen among patient groups by treatment arm. CONCLUSION: Dabigatran etexilate thromboprophylaxis should be initiated 1 to 4h postsurgery. Results from our post-hoc analysis indicate that no loss of efficacy appears to occur if initiation of dabigatran etexilate 220mg needs to be delayed.
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Dahl, Ola E
(författare)
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Rosencher, Nadia
(författare)
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Clemens, Andreas
(författare)
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Hantel, Stefan
(författare)
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Kurth, Andreas A
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för ortopedi
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Ingår i:Thrombosis research: Elsevier BV130:6, s. 871-8761879-24720049-3848
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