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Immune response in ...
Immune response in blood and tumour tissue in patients with metastatic malignant melanoma treated with IL-2, IFN alpha and histamine dihydrochloride.
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Jørkov, Andreas Schjellerup (författare)
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Donskov, Frede (författare)
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Steiniche, Torben (författare)
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visa fler...
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Ternesten-Bratel, Annika (författare)
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Naredi, Peter, 1955 (författare)
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- Hellstrand, Kristoffer, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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Hokland, Marianne (författare)
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visa färre...
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Anticancer research. - 0250-7005. ; 23:1B, s. 537-42
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Interleukin-2 and interferon-alpha are pleiotropic immuno-activating cytokines with clinical efficacy in malignant melanoma. The anti-melanoma activity of these cytokines is believed to result from the triggering of lymphocyte-mediated killing of tumour cells. In ongoing clinical trials, histamine dihydrochloride is used as an adjuvant to IL-2 and IFN-alpha with a view to protecting lymphocytes from oxidative inhibition induced by tumour-infiltrating monocyte/macrophages. In this study, we have serially monitored mononuclear cells in peripheral blood and tumour biopsies from 13 patients with metastatic malignant melanoma treated under a protocol comprising histamine, IFN-alpha and low-dose IL-2. One complete and 3 partial responses were observed, while 3 patients had stable disease and 6 progressed. A trend towards a gradual increase in the absolute number of circulating CD56+/CD3- NK cells in patients maintaining stable disease during therapy was noted. In tumour tissues, the extent of leukocyte infiltration prior to treatment correlated with tumour response. Additional infiltration by NK cells (CD56+) and monocytes during treatment was seen only in responding patients. Patients with progressive disease exhibited a low density of leukocytes infiltrating tumour tissues at the onset of treatment as compared to the surrounding tissues. Our data indicate that the degree and localization of mononuclear infiltration before and during immunotherapy under this protocol may determine therapeutic anti-tumour responses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Antigens
- CD3
- immunology
- Antigens
- CD45
- immunology
- Antigens
- CD57
- immunology
- Antineoplastic Combined Chemotherapy Protocols
- therapeutic use
- Female
- Histamine
- therapeutic use
- Histamine Agonists
- therapeutic use
- Humans
- Immunohistochemistry
- Immunotherapy
- methods
- Interferon-alpha
- administration & dosage
- Interleukin-2
- administration & dosage
- Killer Cells
- Natural
- drug effects
- immunology
- Leukocytes
- Mononuclear
- drug effects
- immunology
- Male
- Melanoma
- immunology
- therapy
- Middle Aged
- Recombinant Proteins
- T-Lymphocytes
- drug effects
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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