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Letrozole increases...
Letrozole increases ovarian growth and Cyp17a1 gene expression in the rat ovary
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Ortega, I. (författare)
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Sokalska, A. (författare)
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Villanueva, J. A. (författare)
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Cress, A. B. (författare)
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Wong, D. H. (författare)
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- Stener-Victorin, Elisabet, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Stanley, S. D. (författare)
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Duleba, A. J. (författare)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282. ; 99:3, s. 889-896
- Relaterad länk:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To evaluate the effects of letrozole on ovarian size and steroidogenesis in vivo, as well as Design: In vivo and in vitro studies. Setting: Research laboratory. Animal(s): Immature Sprague-Dawley female rats. Intervention(s): In vivo effects of letrozole were studied in intact rats receiving either letrozole (90-day Main Outcome Measure(s): Deoxyribonucleic acid synthesis was determined by thymidine Result(s): In vivo, letrozole induced an increase in ovarian size compared with the control group and Conclusion(s): These findings suggest that letrozole exerts potent, but indirect, effect on growth of rat
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- CYP17A1
- letrozole
- ovarian theca-interstitial cells
- proliferation
- steroidogenesis
- theca-interstitial cells
- induced polycystic ovaries
- acute regulatory
- protein
- advanced breast-cancer
- aromatase inhibitors
- luteinizing-hormone
- clomiphene citrate
- androgen receptor
- transgenic
- mice
- messenger-rna
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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