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Three-Dimensional T...
Three-Dimensional Telomeric Analysis of Isolated Circulating Tumor Cells (CTCs) Defines CTC Subpopulations
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- Awe, Julius Adebayo (författare)
- Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,Institutionen för vård och natur,Forskningscentrum för Systembiologi,University of Manitoba, CancerCare Manitoba, Canada ; Sahlgrenska Academy, University of Gothenburg, Sweden
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- Xu, M. C. (författare)
- University of Manitoba, CancerCare Manitoba, Canada
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- Wechsler, J. (författare)
- ScreenCell, Paris, France ; Hôpital Henri Mondor, Créteil, France
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- Benali-Furet, N. (författare)
- ScreenCell, Paris, France
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- Cayre, Y. E. (författare)
- ScreenCell, Paris, France ; Hôpital Robert Debré and Pierre, Marie Curie University, Paris, France
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- Saranchuk, J. (författare)
- University of Manitoba, Canada
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- Drachenberg, D. (författare)
- University of Manitoba, Canada
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- Mai, S. (författare)
- University of Manitoba, CancerCare Manitoba, Canada
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: Translational Oncology. - : Elsevier BV. - 1944-7124 .- 1936-5233. ; 6:1
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Circulating tumor cells (CTCs) have been identified with the potential to serve as suitable biomarkers for tumor stage and progression, but the availability of effective isolation technique(s) coupled with detailed molecular characterization have been the challenges encountered in making CTCs clinically relevant. For the first time, we combined isolation of CTCs using the ScreenCell filtration technique with quantitative analysis of CTC telomeres by TeloView. This resulted in the identification and molecular characterization of different subpopulations of CTCs in the same patient. Three-dimensional (3D) telomeric analysis was carried out on isolated CTCs of 19 patients that consisted of four different tumor types, namely, prostate, colon, breast, melanoma, and one lung cancer cell line. With telomeric analysis of the filter-isolated CTCs, the level of chromosomal instability (CIN) of the CTCs can be determined. Our study shows that subpopulations of CTCs can be identified on the basis of their 3D telomeric properties.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- breast-cancer
- prostate-cancer
- chromosomal rearrangements
- interphase
- nucleus
- peripheral-blood
- organization
- architecture
- survival
- microscopy
- biomarkers
- Natural sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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