Sökning: onr:"swepub:oai:gup.ub.gu.se/184741" >
I-123-FP-Cit and I-...
I-123-FP-Cit and I-123-IBZM SPECT uptake in a prospective normal material analysed with two different semiquantitative image evaluation tools
-
- Jakobson Mo, Susanna, 1968- (författare)
- Umeå universitet,Diagnostisk radiologi
-
- Larsson, Anne (författare)
- Umeå universitet,Radiofysik
-
- Linder, Jan (författare)
- Umeå universitet,Klinisk neurovetenskap
-
visa fler...
-
- Birgander, Richard (författare)
- Umeå universitet,Diagnostisk radiologi
-
- Edenbrandt, Lars, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Göteborgs Universitet, Avdelningen för molekylär och klinisk medicin
-
- Stenlund, Hans (författare)
- Umeå universitet,Epidemiologi och global hälsa
-
- Forsgren, Lars (författare)
- Umeå universitet,Klinisk neurovetenskap
-
- Riklund, Katrine (författare)
- Umeå universitet,Diagnostisk radiologi
-
visa färre...
-
(creator_code:org_t)
- Lippincott Williams & Wilkins, 2013
- 2013
- Engelska.
-
Ingår i: Nuclear Medicine Communications. - : Lippincott Williams & Wilkins. - 0143-3636 .- 1473-5628. ; 34:10, s. 978-989
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective The need for age-adjusted and/or sex-adjusted reference values in dopamine transporter (DAT) and dopamine D2 receptor (D2R) imaging with single-photon emission computed tomography (SPECT) in a longitudinal study of parkinsonian diseases was investigated. We used two different image evaluation tools with a cross-sectional and longitudinal statistical approach.Materials and methods Baseline DAT and/or D2R SPECT were performed in 51 healthy controls (HC), age-matched to patients in an ongoing prospective study on idiopathic parkinsonism. Twenty-four HC were re-examined after 3 years and 21 HC were examined again after 5 years. SPECT was performed with I-123-FP-Cit and I-123-IBZM on a two-headed hybrid gamma camera. Regions of interest and volumes of interest (VOIs) were used for image evaluation. A cross-sectional and longitudinal statistical analysis was carried out.Results Fewer sex-based differences and less age dependency were seen in DAT SPECT uptake ratios compared with D2R SPECT uptake ratios and when comparing uptake ratios obtained with regions of interest against those with VOIs. In the cross-sectional analysis, a significant age-dependent decline was seen in women in both DAT and D2R uptakes with the VOI method but not in men with either evaluation method. In the longitudinal dataset, both a slight decline and increase over time were seen in DAT uptake; however, a general pattern of decrease was seen in both men and women in D2R uptake.Conclusion The choice of the image evaluation method can influence the pattern of sex-based and age-related differences. The results speak for the use of age-stratified reference values for women, in particular when using a VOI method.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- I-123-FP-Cit
- I-123-IBZM
- ageing
- dopamine
- sex
- prospective
- single-photon emission computed
- AGE-RELATED DECLINE
- PARKINSONS-DISEASE
- DOPAMINE TRANSPORTER
- GENDER-DIFFERENCES
- SUBSTANTIA-NIGRA
- HEALTHY CONTROLS
- SEX-DIFFERENCES
- CIT SPECT
- PROGRESSION
- ESTROGEN
- 123I-FP-CIT
- Radiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas