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Mannitol Utilisatio...
Mannitol Utilisation is Required for Protection of Staphylococcus aureus from Human Skin Antimicrobial Fatty Acids
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Kenny, J. G. (författare)
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Moran, J. (författare)
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Kolar, S. L. (författare)
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Ulanov, A. (författare)
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Li, Z. (författare)
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Shaw, L. N. (författare)
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- Josefsson, Elisabet, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Horsburgh, M. J. (författare)
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(creator_code:org_t)
- 2013-07-04
- 2013
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:7
- Relaterad länk:
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https://journals.plo...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mannitol (Mtl) fermentation, with the subsequent production of acid, is a species signature of Staphylococcus aureus, and discriminates it from most other members of the genus. Inactivation of the gene mtlD, encoding Mtl-1-P dehydrogenase was found to markedly reduce survival in the presence of the antimicrobial fatty acid, linoleic acid. We demonstrate that the sugar alcohol has a potentiating action for this membrane-acting antimicrobial. Analysis of cellular metabolites revealed that, during exponential growth, the mtlD mutant accumulated high levels of Mtl and Mtl-P. The latter metabolite was not detected in its isogenic parent strain or a deletion mutant of the entire mtlABFD operon. In addition, the mtlD mutant strain exhibited a decreased MIC for H2O2, however virulence was unaffected in a model of septic arthritis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- BACILLUS-SUBTILIS
- ANTIBACTERIAL ACTIVITY
- STRESS RESISTANCE
- OXIDATIVE
- STRESS
- IN-VIVO
- VIRULENCE
- EXPRESSION
- LIPIDS
- STARVATION
- ABSCESSES
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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