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Emerging trends in ...
Emerging trends in the discovery of natural product antibacterials
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Bologa, C. G. (författare)
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Ursu, O. (författare)
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- Oprea, Tudor I (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Melancon, C. E. (författare)
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Tegos, G. P. (författare)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: Current Opinion in Pharmacology. - : Elsevier BV. - 1471-4892. ; 13:5, s. 678-687
- Relaterad länk:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural product antibacterial drug discovery arena, and to emerging applications driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with exploiting bacterial phenotypes. These efforts have identified a critical mass of natural product antibacterial lead compounds and discovery technologies with high probability of successful implementation against emerging bacterial pathogens.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- I POLYKETIDE SYNTHASES
- ESCHERICHIA-COLI
- GENE CLUSTERS
- BIOSYNTHESIS
- RESISTANCE
- STREPTOMYCES
- ANTIBIOTICS
- BACTERIAL
- INHIBITION
- DIVERSITY
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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