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Blunted Metabolic R...
Blunted Metabolic Responses to Cold and Insulin Stimulation in Brown Adipose Tissue of Obese Humans
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Orava, J. (författare)
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Nuutila, P. (författare)
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Noponen, T. (författare)
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Parkkola, R. (författare)
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Viljanen, T. (författare)
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- Enerbäck, Sven, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Rissanen, A. (författare)
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Pietilainen, K. H. (författare)
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Virtanen, K. A. (författare)
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(creator_code:org_t)
- 2013-06-13
- 2013
- Engelska.
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Ingår i: Obesity. - : Wiley. - 1930-7381. ; 21:11, s. 2279-2287
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Inactive brown adipose tissue (BAT) may predispose to weight gain. This study was designed to measure metabolism in the BAT of obese humans, and to compare it to that in lean subjects. The impact of weight loss on BAT and the association of detectable BAT with various metabolic characteristics were also assessed. Design and Methods: Using positron emission tomography (PET), cold-and insulin-stimulated glucose uptake and blood flow in the BAT of obese and lean humans were quantified. Further, cold-induced glucose uptake was measured in obese subjects before and after a 5-month conventional weight loss. Results: Mean responses in BAT glucose uptake rate to both cold and insulin stimulation were twice as large in lean as in obese subjects. Blood flow in BAT was also lower in obese subjects under cold conditions. The increase in cold-induced BAT glucose uptake rate after weight loss was not statistically significant. Subjects with cold-activated detectable BAT were leaner and had higher whole-body insulin sensitivity than BAT-negative subjects, irrespective of age and gender. Conclusions: The effects of cold and insulin on BAT activity are severely blunted in obesity, and the presence of detectable BAT may contribute to a metabolically healthy status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ENDOTHELIAL FUNCTION
- WEIGHT-LOSS
- GLUCOSE
- SENSITIVITY
- RESISTANCE
- EXPOSURE
- CLAMP
- RATS
- FRONZO RA
- 1979
- AMERICAN JOURNAL OF PHYSIOLOGY
- V237
- PE214
- ATES OF AMERICA
- V109
- P10001
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Obesity
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Till lärosätets databas
- Av författaren/redakt...
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Orava, J.
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Nuutila, P.
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Noponen, T.
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Parkkola, R.
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Viljanen, T.
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Enerbäck, Sven, ...
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visa fler...
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Rissanen, A.
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Pietilainen, K. ...
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Virtanen, K. A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Obesity
- Av lärosätet
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Göteborgs universitet