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Inflammatory cytoki...
Inflammatory cytokines in chronic heart failure: interleukin-8 is associated with adverse outcome. Results from CORONA
- Artikel/kapitelEngelska2014
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LIBRIS-ID:oai:gup.ub.gu.se/193520
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https://gup.ub.gu.se/publication/193520URI
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https://doi.org/10.1093/eurjhf/hft125DOI
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Aim We investigated the ability of prototypical inflammatory cytokines to predict clinical outcomes in a large population of patients with chronic systolic heart failure (HF). Methods and results Serum levels of tumour necrosis factor-alpha (TNF-alpha), soluble TNF receptors type I and II (sTNF-RI and sTNF-RII), and the chemokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) were analysed in 1464 patients with chronic ischaemic systolic HF in the CORONA study, aged >= 60 years, in NYHA class II-IV, and related to the primary endpoint (n = 320), as well as any coronary event (n = 255), all-cause mortality (n = 329), cardiovascular (CV) mortality (n = 268), and the composite endpoint hospitalization from worsening heart failure (WHF) or CV mortality (n = 547). TNF-alpha, sTNF-RI, sTNF-RII, and IL-8, but not MCP-1, were independent predictors of all endpoints except the coronary endpoint in multivariable models including conventional clinical variables. After further adjustment for estimated glomerular filtration rate, the ApoB/ApoA-1 ratio, NT-proBNP, and high-sensitivity C-reactive protein, only IL-8 remained a significant predictor of all endpoints (except the coronary endpoint), while sTNF-RI remained independently associated with CV mortality. Adding IL-8 to the full model led to a significant improvement in net reclassification for all-cause mortality and CV hospitalization, but only a borderline significant improvement for the primary endpoint, CV mortality, and the composite endpoint WHF hospitalization or CV mortality. Conclusion Our study supports a relationship between IL-8 and outcomes in patients with chronic HF. However, the clinical usefulness of IL-8 as a biomarker in an unselected HF population is at present unclear.
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Hulthe, J.
(författare)
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Ueland, T.
(författare)
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McMurray, J.
(författare)
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Wikstrand, John,1938Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xwikjo
(författare)
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Askevold, E. T.
(författare)
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Yndestad, A.
(författare)
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Gullestad, L.
(författare)
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Aukrust, P.
(författare)
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Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Heart Failure: Wiley16:1, s. 68-751388-9842
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Till lärosätets databas
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Nymo, S. H.
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Hulthe, J.
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Ueland, T.
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McMurray, J.
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Wikstrand, John, ...
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Askevold, E. T.
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visa fler...
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Yndestad, A.
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Gullestad, L.
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Aukrust, P.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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European Journal ...
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Göteborgs universitet