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Changes to anti-JCV...
Changes to anti-JCV antibody levels in a Swedish national MS cohort
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Warnke, C. (författare)
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- Ramanujam, R. (författare)
- Karolinska Institutet
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Plavina, T. (författare)
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- Bergström, Tomas, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Goelz, S. (författare)
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Subramanyam, M. (författare)
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- Kockum, I. (författare)
- Karolinska Institutet
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- Rahbar, A. (författare)
- Karolinska Institutet
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Kieseier, B. C. (författare)
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- Holmen, C. (författare)
- Karolinska Institutet
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- Olsson, T. (författare)
- Karolinska Institutet
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- Hillert, J. (författare)
- Karolinska Institutet
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- Fogdell-Hahn, A. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-03-05
- 2013
- Engelska.
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Ingår i: Journal of Neurology Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 84:11, s. 1199-1205
- Relaterad länk:
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https://jnnp.bmj.com...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background The anti-JC virus (JCV) antibody status has been introduced to stratify patients with multiple sclerosis (MS) for higher or lower risk of progressive multifocal leukoencephalopathy (PML). Objective To assess the potential utility of anti-JCV antibody levels for earlier diagnosis or prediction of PML. Methods An analytically validated antibody assay was used to determine serological status, normalised optical density values, and dilution titres for anti-JCV antibodies. The method was applied to stored sera of 1157 patients with MS including five cases of PML, all enrolled in the Swedish pharmacovigilance study for natalizumab (NAT). Anticytomegalovirus (CMV) and antivaricella-zoster (VZV) antibody levels served as controls. Results Prior to treatment with NAT, anti-JCV antibody levels were stable in the anti-JCV positive patients. During therapy, a slight decrease in anti-JCV and anti-VZV antibody levels, but not anti-CMV antibody levels, was observed. All five patients who developed PML showed a mild to moderate increase in anti-JCV antibody levels at time of PML diagnosis; pre-PML samples suggested that this increase might start already prior to diagnosis of PML. Conclusions Treatment initiation with NAT may lead to a slight decrease in anti-JCV and anti-VZV antibody levels, suggestive of a mild suppressive effect of NAT on antibody levels. Our findings in five cases of PML demonstrate that the onset of PML can be accompanied by increasing anti-JCV antibodies in serum. Monitoring of anti-JCV antibody levels could potentially be used as a tool for prediction or earlier diagnosis of PML during NAT treatment for MS. Further studies are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
- MULTIPLE-SCLEROSIS
- NATALIZUMAB TREATMENT
- HUMORAL IMMUNITY
- PROGENITOR CELLS
- GLYCOPROTEIN-E
- VIRUS
- ADHESION
- SURVEILLANCE
- MECHANISMS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Warnke, C.
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Ramanujam, R.
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Plavina, T.
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Bergström, Tomas ...
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Goelz, S.
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Subramanyam, M.
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visa fler...
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Kockum, I.
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Rahbar, A.
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Kieseier, B. C.
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Holmen, C.
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Olsson, T.
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Hillert, J.
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Fogdell-Hahn, A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of Neuro ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet