Sökning: onr:"swepub:oai:gup.ub.gu.se/196031" > Mendelian randomiza...
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000 | 07487naa a2201501 4500 | |
001 | oai:gup.ub.gu.se/196031 | |
003 | SwePub | |
008 | 240910s2013 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-210192 | |
024 | 7 | a https://gup.ub.gu.se/publication/1960312 URI |
024 | 7 | a https://doi.org/10.2337/db13-01282 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2101922 URI |
040 | a (SwePub)gud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Yaghootkar, Hanieh4 aut |
245 | 1 0 | a Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. |
264 | c 2013-09-17 | |
264 | 1 | b American Diabetes Association,c 2013 |
520 | a Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but its causal role remains controversial. We used a Mendelian randomization approach to test the hypothesis that adiponectin causally influences insulin resistance and type 2 diabetes. We used genetic variants at the ADIPOQ gene as instruments to calculate a regression slope between adiponectin levels and metabolic traits (up to 31,000 individuals) and a combination of instrumental variables and summary statistics-based genetic risk scores to test the associations with gold-standard measures of insulin sensitivity (2,969 individuals) and type 2 diabetes (15,960 case subjects and 64,731 control subjects). In conventional regression analyses, a 1-SD decrease in adiponectin levels was correlated with a 0.31-SD (95% CI 0.26-0.35) increase in fasting insulin, a 0.34-SD (0.30-0.38) decrease in insulin sensitivity, and a type 2 diabetes odds ratio (OR) of 1.75 (1.47-2.13). The instrumental variable analysis revealed no evidence of a causal association between genetically lower circulating adiponectin and higher fasting insulin (0.02 SD; 95% CI -0.07 to 0.11; N = 29,771), nominal evidence of a causal relationship with lower insulin sensitivity (-0.20 SD; 95% CI -0.38 to -0.02; N = 1,860), and no evidence of a relationship with type 2 diabetes (OR 0.94; 95% CI 0.75-1.19; N = 2,777 case subjects and 13,011 control subjects). Using the ADIPOQ summary statistics genetic risk scores, we found no evidence of an association between adiponectin-lowering alleles and insulin sensitivity (effect per weighted adiponectin-lowering allele: -0.03 SD; 95% CI -0.07 to 0.01; N = 2,969) or type 2 diabetes (OR per weighted adiponectin-lowering allele: 0.99; 95% CI 0.95-1.04; 15,960 case subjects vs. 64,731 control subjects). These results do not provide any consistent evidence that interventions aimed at increasing adiponectin levels will improve insulin sensitivity or risk of type 2 diabetes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Adiponectin | |
653 | a blood | |
653 | a genetics | |
653 | a Blood Glucose | |
653 | a metabolism | |
653 | a Diabetes Mellitus | |
653 | a Type 2 | |
653 | a blood | |
653 | a genetics | |
653 | a Female | |
653 | a Genetic Predisposition to Disease | |
653 | a Genetic Variation | |
653 | a Humans | |
653 | a Insulin Resistance | |
653 | a genetics | |
653 | a Male | |
653 | a Mendelian Randomization Analysis | |
653 | a Odds Ratio | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Regression Analysis | |
700 | 1 | a Lamina, Claudia4 aut |
700 | 1 | a Scott, Robert A4 aut |
700 | 1 | a Dastani, Zari4 aut |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Warren, Liling L4 aut |
700 | 1 | a Stancáková, Alena4 aut |
700 | 1 | a Buxbaum, Sarah G4 aut |
700 | 1 | a Lyytikäinen, Leo-Pekka4 aut |
700 | 1 | a Henneman, Peter4 aut |
700 | 1 | a Wu, Ying4 aut |
700 | 1 | a Cheung, Chloe Y Y4 aut |
700 | 1 | a Pankow, James S4 aut |
700 | 1 | a Jackson, Anne U4 aut |
700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732 |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Ballantyne, Christie M4 aut |
700 | 1 | a Xie, Weijia4 aut |
700 | 1 | a Bergman, Richard N4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a el Bouazzaoui, Fatiha4 aut |
700 | 1 | a Collins, Francis S4 aut |
700 | 1 | a Dunn, Sandra H4 aut |
700 | 1 | a Dupuis, Josee4 aut |
700 | 1 | a Forouhi, Nita G4 aut |
700 | 1 | a Gillson, Christopher4 aut |
700 | 1 | a Hattersley, Andrew T4 aut |
700 | 1 | a Hong, Jaeyoung4 aut |
700 | 1 | a Kähönen, Mika4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Kedenko, Lyudmyla4 aut |
700 | 1 | a Kronenberg, Florian4 aut |
700 | 1 | a Doria, Alessandro4 aut |
700 | 1 | a Assimes, Themistocles L4 aut |
700 | 1 | a Ferrannini, Ele4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Hao, Ke4 aut |
700 | 1 | a Häring, Hans4 aut |
700 | 1 | a Knowles, Joshua W4 aut |
700 | 1 | a Lindgren, Cecilia M4 aut |
700 | 1 | a Nolan, John J4 aut |
700 | 1 | a Paananen, Jussi4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Quertermous, Thomas4 aut |
700 | 1 | a Smith, Ulf,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsmiul |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
700 | 1 | a the RISC Consortium,4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Loos, Ruth J F4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Morris, Andrew D4 aut |
700 | 1 | a Vasan, Ramachandran S4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Teslovich, Tanya M4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a van Dijk, Ko Willems4 aut |
700 | 1 | a Viikari, Jorma S4 aut |
700 | 1 | a Zhu, Na4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Ingelsson, Erik4 aut |
700 | 1 | a Semple, Robert K4 aut |
700 | 1 | a Sinaiko, Alan R4 aut |
700 | 1 | a Palmer, Colin N A4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Lam, Karen S L4 aut |
700 | 1 | a Paulweber, Bernhard4 aut |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a van Duijn, Cornelia4 aut |
700 | 1 | a Raitakari, Olli T4 aut |
700 | 1 | a Bidulescu, Aurelian4 aut |
700 | 1 | a Wareham, Nick J4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Waterworth, Dawn M4 aut |
700 | 1 | a Lawlor, Debbie A4 aut |
700 | 1 | a Meigs, James B4 aut |
700 | 1 | a Richards, J Brent4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
773 | 0 | t Diabetesd : American Diabetes Associationg 62:10, s. 3589-3598q 62:10<3589-3598x 1939-327Xx 0012-1797 |
856 | 4 | u https://diabetes.diabetesjournals.org/content/diabetes/62/10/3589.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/196031 |
856 | 4 8 | u https://doi.org/10.2337/db13-0128 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210192 |
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