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Loss of heterozygos...
Loss of heterozygosity of 3p markers in neuroblastoma tumours implicate a tumour-suppressor locus distal to the FHIT gene.
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Ejeskär, K (författare)
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Aburatani, H (författare)
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- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Kogner, P (författare)
- Karolinska Institutet
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Martinsson, T (författare)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 1998
- 1998
- Engelska.
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Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 77:11, s. 1787-91
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Abstract
Ämnesord
Stäng
- Neuroblastoma is a heterogeneous childhood tumour of the sympathetic nervous system, in which deletions of chromosomal region 1p and amplification of the MYCN oncogene correlate with aggressive tumour behaviour. However, the majority of neuroblastoma tumours show neither of these aberrations, indicating that other chromosomal regions may be involved in tumorigenesis. Here, we report findings of loss of heterozygosity (LOH) on chromosome 3. In our neuroblastoma material, nine of 59 (15.3%) tested tumours showed allelic loss of chromosome 3p markers. We found significant clinical and biological differences between tumours with the loss of one entire chromosome 3 vs tumours with partial loss in chromosome region 3p. All children with tumours with whole chromosome 3 loss are long-term survivors, whereas all children with tumours showing partial 3p LOH have died from tumour progression. A consensus region found to be deleted in all the tumours with 3p deletions was defined by markers D3S1286 and D3S1295, i.e. 3p25.3-p14.3, distal to the FHIT gene.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Acid Anhydride Hydrolases
- Child
- Child
- Preschool
- Chromosomes
- Human
- Pair 3
- Female
- Gene Amplification
- Genes
- Tumor Suppressor
- Genes
- myc
- Humans
- Infant
- Loss of Heterozygosity
- Male
- Neoplasm Proteins
- Neuroblastoma
- genetics
- mortality
- Prognosis
- Proteins
- genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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