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Evolving Character ...
Evolving Character of Chronic Central Nervous System HIV Infection
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Price, Richard W. (författare)
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Spudich, Serena S. (författare)
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Peterson, Julia (författare)
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Joseph, Sarah (författare)
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Fuchs, Dietmar (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Gisslén, Magnus, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Swanstrom, Ronald (författare)
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(creator_code:org_t)
- 2014-04-08
- 2014
- Engelska.
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Ingår i: Seminars in Neurology. - : Georg Thieme Verlag KG. - 0271-8235 .- 1098-9021. ; 34:1, s. 7-13
- Relaterad länk:
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https://cdr.lib.unc....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) begins early in systemic infection and continues throughout its untreated course. Despite a common cerebrospinal fluid inflammatory response, it is usually neurologically asymptomatic for much of this course, but can evolve in some individuals to HIV-associated dementia (HAD), a severe encephalopathy with characteristic cognitive and motor dysfunction. While widespread use of combination antiretroviral therapy (ART) has led to a marked decline in both the CNS infection and its neurologic severe consequence, HAD continues to afflict individuals presenting with advanced systemic infection in the developed world and a larger number in resource-poor settings where ART is more restricted. Additionally, milder CNS injury and dysfunction have broader prevalence, including in those treated with ART. Here we review the history and evolving nomenclature of HAD, its viral pathogenesis, clinical presentation and diagnosis, and treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- cerebrospinal fluid
- treatment
- HIV
- dementia
- brain
- biomarkers
- inflammation
- AIDS DEMENTIA COMPLEX
- CEREBROSPINAL-FLUID NEOPTERIN
- PLASMA VIRAL LOAD
- CD8(+) T-CELLS
- ANTIRETROVIRAL THERAPY
- IMMUNE ACTIVATION
- BIOMARKERS
- DISEASE
- MARKERS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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