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Magnesium Is Not Co...
Magnesium Is Not Consistently Neuroprotective for Perinatal Hypoxia-Ischemia in Term-Equivalent Models in Preclinical Studies: A Systematic Review
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Galinsky, R. (författare)
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Bennet, L. (författare)
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Groenendaal, F. (författare)
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Lear, C. A. (författare)
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Tan, S. (författare)
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van Bel, F. (författare)
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Juul, S. E. (författare)
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Robertson, N. J. (författare)
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- Mallard, Carina, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Gunn, A. J. (författare)
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(creator_code:org_t)
- 2014-05-21
- 2014
- Engelska.
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Ingår i: Developmental Neuroscience. - : S. Karger AG. - 0378-5866 .- 1421-9859. ; 36:2, s. 73-82
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https://www.karger.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but that it has no effect on death or disability. Because of this inconsistency, it remains controversial whether MgSO4 is clinically neuroprotective and, thus, it is unclear whether it would be appropriate to test MgSO4 for treatment of encephalopathy in term infants. We therefore systematically reviewed the preclinical evidence for neuroprotection with MgSO4 before or after hypoxic-ischemic encephalopathy (HIE) in term-equivalent perinatal and adult animals. The outcomes were highly inconsistent between studies. Although there were differences in dose and timing of administration, there was evidence that beneficial effects of MgSO4 were associated with confounding mild hypothermia and, strikingly, the studies that included rigorous maintenance of environmental temperature or body temperature consistently suggested a lack of effect. On balance, these preclinical studies suggest that peripherally administered MgSO4 is unlikely to be neuroprotective. Rigorous testing in translational animal models of perinatal HIE is needed before MgSO4 should be considered in clinical trials for encephalopathy in term infants. (C) 2014 S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Asphyxia
- Brain injury
- Cerebral palsy
- Hypoxic-ischemic encephalopathy
- Magnesium sulfate
- FOCAL CEREBRAL-ISCHEMIA
- NEWBORN PIGLET
- BRAIN-DAMAGE
- SULFATE
- TREATMENT
- MILD HYPOTHERMIA
- BIRTH ASPHYXIA
- INTRAVENOUS MAGNESIUM
- HIPPOCAMPAL SLICES
- ARTERY OCCLUSION
- PRETERM INFANTS
- Developmental Biology
- Neurosciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Galinsky, R.
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Bennet, L.
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Groenendaal, F.
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Lear, C. A.
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Tan, S.
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van Bel, F.
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visa fler...
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Juul, S. E.
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Robertson, N. J.
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Mallard, Carina, ...
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Gunn, A. J.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Developmental Ne ...
- Av lärosätet
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Göteborgs universitet