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Sökning: onr:"swepub:oai:gup.ub.gu.se/203690" > The impact of eleva...

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FältnamnIndikatorerMetadata
00003448naa a2200493 4500
001oai:gup.ub.gu.se/203690
003SwePub
008240528s2014 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2036902 URI
0247 a https://doi.org/10.1016/j.dld.2014.06.0102 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Benito de Valle, Mariau Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut
2451 0a The impact of elevated serum IgG4 levels in patients with primary sclerosing cholangitis
264 1b Elsevier BV,c 2014
520 a Background: Elevated IgG4 levels have been reported among patients with primary sclerosing cholangitis. Epidemiological data has only been provided from tertiary centres. Aims: To investigate the prevalence of elevated IgG4 levels and to compare prognosis between patients with and without elevated IgG4 levels in serum in two European cohorts of patients with primary sclerosing cholangitis. Methods: Serum IgG4-levels were measured in a consecutive series of patients from Berlin, and retrospectively collected in a population-based cohort from Sweden (total N = 345). Cox's proportional hazard analysis was used to calculate relative risks for liver-related death or liver transplantation and cholangiocarcinoma. Results: Elevated IgG4 values were demonstrated in 10% of patients. A previous history of pancreatitis, combined intra-and extrahepatic biliary involvement and jaundice were independently associated with elevated IgG4 in multivariate analysis. IgG4 status was not associated with an increased risk for the combined endpoint liver-related death or liver transplantation or cholangiocarcinoma. Conclusion: The prevalence of elevated IgG4 values among European patients with primary sclerosing cholangitis is similar to what previously has been reported from the United States. Elevated IgG4 was not associated with an increased risk of liver transplantation or liver-related death or cholangiocarcinoma.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a IgG4 status
653 a Prevalence
653 a Survival
653 a IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS
653 a THERAPY
653 a SPECTRUM
653 a G4
653 a Gastroenterology & Hepatology
7001 a Muller, T.4 aut
7001 a Bjornsson, E.4 aut
7001 a Otten, M.4 aut
7001 a Volkmann, M.4 aut
7001 a Guckelberger, O.4 aut
7001 a Wiedenmann, B.4 aut
7001 a Sadik, Riadh,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xsadri
7001 a Schott, E.4 aut
7001 a Andersson, M.4 aut
7001 a Berg, T.4 aut
7001 a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo
7102 a Göteborgs universitetb Institutionen för medicin4 org
7730 t Digestive and Liver Diseased : Elsevier BVg 46:10, s. 903-908q 46:10<903-908x 1590-8658
8564 8u https://gup.ub.gu.se/publication/203690
8564 8u https://doi.org/10.1016/j.dld.2014.06.010

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