Sökning: onr:"swepub:oai:gup.ub.gu.se/206443" > CETP TaqIB genotype...
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000 | 05769naa a2200517 4500 | |
001 | oai:gup.ub.gu.se/206443 | |
003 | SwePub | |
008 | 240910s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2064432 URI |
024 | 7 | a https://doi.org/10.1016/j.alcohol.2014.08.0112 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mehlig, Kirsten,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xmehki |
245 | 1 0 | a CETP TaqIB genotype modifies the association between alcohol and coronary heart disease: The INTERGENE case-control study |
264 | 1 | b Elsevier BV,c 2014 |
520 | a Alcohol consumption at moderate levels has been associated with decreased risk of coronary heart disease (CHD). However, the cardio-protective effect of alcohol may be restricted to subjects with a particular genotype of the cholesteryl ester transfer protein (CETP) polymorphism. There is evidence for this from one study in men, but the finding has not been confirmed since. The present study specifically re-examines the potential modification of the association between alcohol consumption and CHD by the CETP TaqIB (rs708272) polymorphism in a sample including both men and women. The INTERGENE case-control study consists of 618 patients with CHD and 2921 control subjects, of whom 19% were homozygous for the CETP TaqIB B2 allele. Alcohol consumption was categorized into sex-specific tertiles of ethanol intake, with non-drinkers constituting a separate category. Logistic regression was used to determine the association between CHD with genotype, ethanol intake, and their interaction. Participants with intermediate ethanol intake (2nd tertile) had lower risk of CHD than those with low ethanol intake (odds ratio [OR] = 0.65; 95% confidence interval [Cl] 0.50-0.85). The strongest protective association was seen in the CETP TaqIB B2 homozygotes for intermediate vs. low ethanol intake (odds ratio OR = 0.21; 95% CI 0.10-0.44). The interaction between ethanol intake and genotype was statistically significant (p = 0.008), and of similar size in men and women though significant only in men (p = 0.01). The effect modification could not be explained by differences in lifestyle, socioeconomics, or alcohol-related biological variables such as HDL-cholesterol. Our study is the first to replicate previous findings of an effect modification in men. It gives only suggestive results for women, possibly due to the small number of female cases (n = 165). The prevented fraction for the favorable combination of genotype and alcohol consumption is about 6%, a value suggesting that the cardio-protective effect of moderate alcohol consumption applies only to a small segment of the general population. (C) 2014 The Authors. Published by Elsevier Inc. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Coronary heart disease | |
653 | a Alcohol | |
653 | a CETP polymorphism | |
653 | a Gene-environment interaction | |
653 | a Prevented | |
653 | a HIGH-DENSITY-LIPOPROTEIN | |
653 | a ESTER TRANSFER PROTEIN | |
653 | a RISK | |
653 | a CHOLESTEROL | |
653 | a CONSUMPTION | |
653 | a GENE | |
653 | a POLYMORPHISM | |
653 | a HYPOTHESIS | |
653 | a PATTERNS | |
700 | 1 | a Strandhagen, Elisabeth,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xstrel |
700 | 1 | a Svensson, Per-Arne,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsvper |
700 | 1 | a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan |
700 | 1 | a Torén, Kjell,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine4 aut0 (Swepub:gu)xtorkj |
700 | 1 | a Thelle, Dag,d 1942u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xtheda |
700 | 1 | a Lissner, Lauren,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xlisla |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org |
773 | 0 | t Alcohold : Elsevier BVg 48:7, s. 695-700q 48:7<695-700x 0741-8329 |
856 | 4 | u https://doi.org/10.1016/j.alcohol.2014.08.011 |
856 | 4 8 | u https://gup.ub.gu.se/publication/206443 |
856 | 4 8 | u https://doi.org/10.1016/j.alcohol.2014.08.011 |
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