Sökning: onr:"swepub:oai:gup.ub.gu.se/210384" > Low-level cadmium e...
Fältnamn | Indikatorer | Metadata |
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000 | 05426naa a2200601 4500 | |
001 | oai:gup.ub.gu.se/210384 | |
003 | SwePub | |
008 | 240910s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:d4846293-9d25-4a54-8ffe-206cfd0da335 | |
009 | oai:research.chalmers.se:5c56eac6-16f7-4951-b55e-1cff7f168b93 | |
024 | 7 | a https://gup.ub.gu.se/publication/2103842 URI |
024 | 7 | a https://doi.org/10.1136/oemed-2014-1022792 DOI |
024 | 7 | a https://lup.lub.lu.se/record/47376162 URI |
024 | 7 | a https://research.chalmers.se/publication/2103842 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wallin, Mariau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,University of Gothenburg4 aut0 (Swepub:cth)claessom |
245 | 1 0 | a Low-level cadmium exposure and effects on kidney function |
264 | c 2014-10-06 | |
264 | 1 | b BMJ,c 2014 |
520 | a Objectives The nephrotoxicity of cadmium at low levels of exposure, measured by urinary cadmium, has recently been questioned since co-excretion of cadmium and proteins may have causes other than cadmium toxicity. The aim of this study was to explore the relation between kidney function and low or moderate cadmium levels, measured directly in kidney biopsies. Methods We analysed cadmium in kidney biopsies (K-Cd), blood (B-Cd) and urine (U-Cd) from 109 living kidney donors in a cross-sectional study. We measured glomerular filtration rate (GFR), cystatin C in serum, albumin, -2-microglobulin (B2M), retinol-binding protein (RBP), -1-microglobulin (A1M), N-acetyl--d-glucosaminidase and kidney injury molecule 1 (KIM-1) in 24h and overnight urine. Results We found significant positive associations between A1M excretion and K-Cd in multiple regression models including age, sex, weight, smoking and urinary flow rate. This association was also present in never-smokers. A1M was also positively associated with B-Cd and U-Cd. GFR and the other biomarkers of kidney function were not associated with K-Cd. GFR estimated from serum cystatin C showed a very poor correlation with measured GFR. KIM-1, RBP and possibly albumin were positively associated with U-Cd, but only in overnight urine. No associations were found with B2M. Conclusions Our results suggest that A1M in urine is a sensitive biomarker for effects of low-level cadmium exposure. A few associations between other renal biomarkers and U-Cd, but not K-Cd, were probably caused by physiological co-excretion or chance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
653 | a GLOMERULAR-FILTRATION-RATE | |
653 | a URINARY CADMIUM | |
653 | a RENAL-FUNCTION | |
653 | a DISEASE | |
653 | a ASSOCIATIONS | |
653 | a POPULATION | |
653 | a CREATININE | |
653 | a BIOMARKERS | |
653 | a EXCRETION | |
653 | a PERFORMANCE | |
653 | a Public | |
653 | a Environmental & Occupational Health | |
653 | a URINARY CADMIUM | |
700 | 1 | a Sällsten, Gerd,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,University of Gothenburg4 aut0 (Swepub:gu)xsalge |
700 | 1 | a Lundh, Thomasu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-tlu |
700 | 1 | a Barregård, Lars,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,University of Gothenburg4 aut0 (Swepub:gu)xbarrl |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin4 org |
773 | 0 | t Occupational and Environmental Medicined : BMJg 71:12, s. 848-854q 71:12<848-854x 1351-0711x 1470-7926 |
856 | 4 | u https://oem.bmj.com/content/71/12/848.full.pdf |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25286916?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1136/oemed-2014-102279y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/210384 |
856 | 4 8 | u https://doi.org/10.1136/oemed-2014-102279 |
856 | 4 8 | u https://lup.lub.lu.se/record/4737616 |
856 | 4 8 | u https://research.chalmers.se/publication/210384 |
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