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Blood group glycosp...
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Lindström, K
(författare)
Blood group glycosphingolipid expression in kidney of an individual with the rare blood group A1 Le(a-b+) p phenotype: absence of blood group structures based on the globoseries.
- Artikel/kapitelEngelska1996
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LIBRIS-ID:oai:gup.ub.gu.se/211787
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https://gup.ub.gu.se/publication/211787URI
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Ämneskategori:art swepub-publicationtype
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Total neutral glycolipid fractions were isolated from kidney and ureter tissue obtained at autopsy of an individual of the rare blood group A1 Le(a-b+) p. The amount of glycolipids isolated were 3.7 and 2.5 mg g-1 dry tissue weight for the kidney and ureter tissue, which is in the range of reference blood group P kidneys. Part of the kidney glycolipid fraction was subfractionated by HPLC. Glycolipid compounds were structurally characterized by thin-layer chromatography (chemical detection and immunostaining with monoclonal antibodies), proton NMR spectroscopy and mass spectrometry. Globotriaosyl- and globotetraosyl-ceramides, which are the major compounds in kidneys of P individuals, were absent in the p kidney, and a comparatively increased amount of monoglycosyl- and lactosylceramides was found. A shift to longer fatty acyl chains in the ceramide part of lactosylceramides was noted. Elongated globoseries compounds with five to seven sugar residues, including the blood group A type 4 chain structure, were lacking. A slight increase in neolactotetraosyl- and blood group X pentaglycosyl-ceramides was noticed. The study confirms an enzymatic block in the conversion of lactosylceramide to elongated globoseries compounds in the kidney tissue similar to that of erythrocytes of p individuals.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
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Animals
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Antibodies
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Monoclonal
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Antibody Specificity
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Blood Group Antigens
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biosynthesis
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chemistry
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Chromatography
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High Pressure Liquid
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Chromatography
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Thin Layer
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Female
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Globosides
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biosynthesis
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chemistry
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Glycolipids
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biosynthesis
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chemistry
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isolation & purification
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Glycosphingolipids
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biosynthesis
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chemistry
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isolation & purification
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Humans
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Kidney
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chemistry
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metabolism
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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P Blood-Group System
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genetics
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Phenotype
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Ureter
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chemistry
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metabolism
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jovall, Per-Åke
(författare)
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Ghardashkani, S
(författare)
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Samuelsson, B E
(författare)
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Breimer, Michael,1951Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xbremi
(författare)
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Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Glycoconjugate journal13:2, s. 307-130282-0080
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