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Sökning: onr:"swepub:oai:gup.ub.gu.se/213652" > The impact of coron...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004179naa a2200553 4500
001oai:gup.ub.gu.se/213652
003SwePub
008240528s2014 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2136522 URI
0247 a https://doi.org/10.1186/s12881-014-0140-32 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Haver, V. G.4 aut
2451 0a The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)
264 c 2014-12-21
264 1b Springer Science and Business Media LLC,c 2014
520 a Background: Recent genome-wide association studies have identified multiple loci that are associated with an increased risk of developing coronary artery disease (CAD). The impact of these loci on the disease severity and prognosis of ischemic heart failure due to CAD is currently unknown. Methods: We undertook association analysis of 7 single nucleotide polymorphism (rs599839, rs17465637, rs2972147, rs6922269, rs1333049, rs501120, and rs17228212) at 7 well established CAD risk loci (1p13.3, 1q41, 2q36.3, 6q25.1, 9p21.3, 10q11.21, and 15q22.33, respectively) in 3,320 subjects diagnosed with systolic heart failure of ischemic aetiology and participating in the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA) trial. The primary outcome was the composite of time to first event of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke, secondary outcomes included mortality and hospitalization due to worsening heart failure. Results: None of the 7 loci were significantly associated with the primary composite endpoint of the CORONA trial (death from cardiovascular cases, nonfatal myocardial infarction, and nonfatal stroke). However, the 1p13.3 locus (rs599839) showed evidence for association with all-cause mortality (after adjustment for covariates; HR 0.74, 95% CI [0.61 to 0.90]; P = 0.0025) and we confirmed the 1p13.3 locus (rs599839) to be associated with lipid parameters (total cholesterol (P = 1.1x10(-4)), low-density lipoprotein levels (P = 3.5 x 10(-7)) and apolipoprotein B (P = 2.2 x 10(-10))). Conclusion: Genetic variants strongly associated with CAD risk are not associated with the severity and outcome of ischemic heart failure. The observed association of the 1p13.3 locus with all-cause mortality requires confirmation in further studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Coronary artery disease
653 a Heart failure
653 a Genetics
653 a Healthy ageing
653 a SNP
653 a SUSCEPTIBILITY LOCI
653 a CARDIOMYOPATHY
653 a CHOLESTEROL
653 a DESIGN
653 a 9P21
653 a Genetics & Heredity
7001 a Verweij, N.4 aut
7001 a Kjekshus, J.4 aut
7001 a Fox, J. C.4 aut
7001 a Wedel, H.4 aut
7001 a Wikstrand, John,d 1938u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xwikjo
7001 a Van Gilst, W. H.4 aut
7001 a de Boer, R. A.4 aut
7001 a van Veldhuisen, D. J.4 aut
7001 a van der Harst, P.4 aut
7102 a Göteborgs universitetb Wallenberglaboratoriet4 org
7730 t Bmc Medical Geneticsd : Springer Science and Business Media LLCg 15:140q 15:140x 1471-2350
8564 u https://bmcmedgenet.biomedcentral.com/track/pdf/10.1186/s12881-014-0140-3
8564 8u https://gup.ub.gu.se/publication/213652
8564 8u https://doi.org/10.1186/s12881-014-0140-3

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