Sökning: onr:"swepub:oai:gup.ub.gu.se/215650" >
Neural Control of t...
Neural Control of the Circulation: How Sex and Age Differences Interact in Humans
-
Joyner, M. J. (författare)
-
Barnes, J. N. (författare)
-
Hart, E. C. (författare)
-
visa fler...
-
- Wallin, Gunnar B, 1936 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
-
Charkoudian, N. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2014-12-23
- 2015
- Engelska.
-
Ingår i: Comprehensive Physiology. - : Wiley. - 2040-4603. ; 5:1, s. 193-215
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The autonomic nervous system is a key regulator of the cardiovascular system. In this review, we focus on how sex and aging influence autonomic regulation of blood pressure in humans in an effort to understand general issues related to the cardiovascular system as a whole. Younger women generally have lower blood pressure and sympathetic activity than younger men. However, both sexes show marked interindividual variability across age groups with significant overlap seen. Additionally, while men across the lifespan show a clear relationship between markers of whole body sympathetic activity and vascular resistance, such a relationship is not seen in young women. In this context, the ability of the sympathetic nerves to evoke vasoconstriction is lower in young women likely as a result of concurrent beta(2)-mediated vasodilation that offsets alpha-adrenergic vasoconstriction. These differences reflect both central sympatho-inhibitory effects of estrogen and also its influence on peripheral vasodilation at the level of the vascular smooth muscle and endothelium. By contrast postmenopausal women show a clear relationship between markers of whole body sympathetic traffic and vascular resistance, and sympathetic activity rises progressively in both sexes with aging. These major findings in humans are discussed in the context of differences in population-based trends in blood pressure and orthostatic intolerance. The many areas where there is little sex-specific data on how the autonomic nervous system participates in the regulation of the human cardiovascular system are highlighted. (C) 2015 American Physiological Society.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- SYMPATHETIC-NERVE ACTIVITY
- ARTERIAL-BLOOD-PRESSURE
- BODY
- NEGATIVE-PRESSURE
- HEART-RATE-VARIABILITY
- GENDER-DIFFERENCES
- HEALTHY
- HUMANS
- NITRIC-OXIDE
- NORADRENALINE SPILLOVER
- BAROREFLEX SENSITIVITY
- AUTONOMIC SUPPORT
- Physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas