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Dynamics and Stabil...
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Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden & Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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Cambridge :Elsevier BV,2015
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/219470
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https://gup.ub.gu.se/publication/219470URI
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https://doi.org/10.1016/j.chom.2015.04.004DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-29962URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Roswall, JosefineGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, Hallands Hospital Halmstad, Halmstad, Sweden & Göteborg Paediatric Growth Research Center, Department of Paediatrics, the University of Gothenburg, Queen Silvia Children’s Hospital, Gothenburg, Sweden(Swepub:gu)xanjos
(författare)
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Peng, Y. Q.BGI-Shenzhen, Shenzhen, China &Department of Biology, University of Copenhagen, Copenhagen, Denmark
(författare)
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Feng, Qing-Ping
(författare)
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Jia, H. J.BGI-Shenzhen, Shenzhen, China
(författare)
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Kovatcheva-Datchary, PetiaGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xkovpe
(författare)
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Liu, Y
(författare)
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Xia, Y.BGI-Shenzhen, Shenzhen, China
(författare)
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Xie, H. L.BGI-Shenzhen, Shenzhen, China
(författare)
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Zhong, H. Z.BGI-Shenzhen, Shenzhen, China
(författare)
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Khan, Muhammad TanweerGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xkhamu
(författare)
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Zhang, J. F.BGI-Shenzhen, Shenzhen, China
(författare)
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Li, J. H.BGI-Shenzhen, Shenzhen, China
(författare)
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Xiao, L.BGI-Shenzhen, Shenzhen, China
(författare)
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Al-Aama, J.BGI-Shenzhen, Shenzhen, China & Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia
(författare)
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Zhang, D. Y.BGI-Shenzhen, Shenzhen, China
(författare)
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Lee, Ying ShiuanGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xleeyi
(författare)
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Kotowska, D.Department of Biology, University of Copenhagen, Copenhagen, Denmark
(författare)
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Colding, C.Department of Biology, University of Copenhagen, Copenhagen, Denmark
(författare)
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Tremaroli, Valentina,1978Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xtreva
(författare)
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Yin, Y.BGI-Shenzhen, Shenzhen, China
(författare)
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Bergman, StefanGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Göteborg Paediatric Growth Research Center, Department of Paediatrics, the University of Gothenburg, Queen Silvia Children’s Hospital, Gothenburg & Research and Development Center Spenshult, Oskarström, Sweden(Swepub:hh)steber
(författare)
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Xu, X.BGI-Shenzhen, Shenzhen, China
(författare)
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Madsen, L.Department of Biology, University of Copenhagen, Copenhagen, Denmark & National Institute of Nutrition and Seafood Research, Bergen, Norway
(författare)
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Kristiansen, K.BGI-Shenzhen, Shenzhen, China & Department of Biology, University of Copenhagen, Copenhagen, Denmark
(författare)
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Dahlgren, Jovanna,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Göteborg Paediatric Growth Research Center, Department of Paediatrics, the University of Gothenburg, Queen Silvia Children’s Hospital, Gothenburg &(Swepub:gu)xdajov
(författare)
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Jun, W.BGI-Shenzhen, Shenzhen, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark, Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia, Macau University of Science and Technology, Avenida Wai long, Taipa, China & Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong
(författare)
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Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cell Host & MicrobeCambridge : Elsevier BV17:5, s. 690-7031931-31281934-6069
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Till lärosätets databas
- Av författaren/redakt...
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Bäckhed, Fredrik ...
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Roswall, Josefin ...
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Peng, Y. Q.
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Feng, Qing-Ping
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Jia, H. J.
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Kovatcheva-Datch ...
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visa fler...
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Liu, Y
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Xia, Y.
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Xie, H. L.
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Zhong, H. Z.
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Khan, Muhammad T ...
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Zhang, J. F.
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Li, J. H.
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Xiao, L.
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Al-Aama, J.
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Zhang, D. Y.
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Lee, Ying Shiuan
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Kotowska, D.
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Colding, C.
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Tremaroli, Valen ...
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Yin, Y.
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Bergman, Stefan
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Xu, X.
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Madsen, L.
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Kristiansen, K.
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Dahlgren, Jovann ...
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Jun, W.
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visa färre...
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Cell Host & Micr ...
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Göteborgs universitet
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Högskolan i Halmstad