Evaluation of cationic micropeptides derived from the innate immune system as inhibitors of marine biofouling

• A series of 13 short synthetic amphiphilic cationic micropeptides, derived from the antimicrobial iron-binding innate defence protein lactoferrin, have been evaluated for their capacity to inhibit the marine fouling process. The whole biofouling process was studied and microfouling organisms such as marine bacteria and microalgae were included as well as the macrofouling barnacle Balanus improvisus. In total 19 different marine fouling organisms (18 microfoulers and one macrofouler) were included and both the adhesion and growth of the microfoulers were investigated. It was shown that the majority of the peptides inhibited barnacle cyprid settlement via a reversible nontoxic mechanism, with IC50 values as low as 0.5 mu g ml(-1). Six peptides inhibited adhesion and growth of microorganisms. Two of these were particularly active against the microfoulers with MIC-values ranging between 0.01 and 1 mu g ml(-1), which is comparable with the commercial reference antifoulant SeaNine.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology (hsv//eng)

Nyckelord

antifouling

innate defence

nontoxic

peptides

amphiphilic

SYNTHETIC ANTIMICROBIAL PEPTIDOMIMETICS

BARNACLE BALANUS-IMPROVISUS

ANTIFOULING COMPOUNDS

ANTIBACTERIAL PEPTIDES

BOVINE LACTOFERRIN

RELEASE COATINGS

NATURAL-PRODUCTS

FOULING-RELEASE

ANALOGS

STABILITY

Biotechnology & Applied Microbiology

Marine & Freshwater Biology

XTER SC

1993

BIOFOULING

V7

P97

amphiphilic

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)