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Risk of Stroke in C...
Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials
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Abdul-Rahim, A. H. (författare)
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Perez, A. C. (författare)
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Fulton, R. L. (författare)
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Jhund, P. S. (författare)
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Latini, R. (författare)
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Tognoni, G. (författare)
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- Wikstrand, John, 1938 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Kjekshus, J. (författare)
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Lip, G. Y. (författare)
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Maggioni, A. P. (författare)
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Tavazzi, L. (författare)
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Lees, K. R. (författare)
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McMurray, J. J. (författare)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2015
- 2015
- Engelska.
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Ingår i: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 131:17
- Relaterad länk:
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https://www.ahajourn...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Our aim was to describe the incidence and predictors of stroke in patients who have heart failure without atrial fibrillation (AF). METHODS AND RESULTS: We pooled 2 contemporary heart failure trials, the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza cardiaca-Heart Failure trial (GISSI-HF). Of the 9585 total patients, 6054 did not have AF. Stroke occurred in 165 patients (4.7%) with AF and in 206 patients (3.4%) without AF (rates 16.8/1000 patient-years and 11.1/1000 patient-years, respectively). Using Cox proportional-hazards models, we identified the following independent predictors of stroke in patients without AF (ranked by chi(2) value): age (hazard ratio, 1.34; 95% confidence interval, 1.18-1.63 per 10 years), New York Heart Association class (1.60, 1.21-2.12 class III/IV versus II), diabetes mellitus treated with insulin (1.87, 1.22-2.88), body mass index (0.74, 0.60-0.91 per 5 kg/m(2) up to 30), and previous stroke (1.81, 1.19-2.74). N-terminal pro B-type natriuretic peptide (available in 2632 patients) was also an independent predictor of stroke (hazard ratio, 1.31; 1.11-1.57 per log unit) when added to this model. With the use of a risk score formulated from these predictors, we found that patients in the upper third of risk had a rate of stroke that approximated the risk in patients with AF. CONCLUSIONS: A small number of demographic and clinical variables identified a subset of patients who have heart failure without AF at a high risk of stroke.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Adult
- Aged
- Aged
- 80 and over
- Atrial Fibrillation/etiology
- Benzimidazoles/therapeutic use
- Biological Markers/blood
- Cardiovascular Agents/therapeutic use
- Diabetes Mellitus
- Type 1/complications
- Fatty Acids
- Omega-3/ therapeutic use
- Female
- Fluorobenzenes/ therapeutic use
- Follow-Up Studies
- Heart Failure/complications/ drug therapy
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors/ therapeutic use
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Natriuretic Peptide
- Brain/ blood
- Peptide Fragments/ blood
- Proportional Hazards Models
- Pyrimidines/ therapeutic use
- Randomized Controlled Trials as Topic
- Risk Factors
- Stroke/epidemiology/ etiology/prevention & control
- Stroke Volume
- Sulfonamides/ therapeutic use
- Tetrazoles/therapeutic use
- atrial fibrillation
- heart failure
- sinus rhythm
- stroke
- ventricular ejection fraction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Abdul-Rahim, A. ...
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Perez, A. C.
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Fulton, R. L.
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Jhund, P. S.
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Latini, R.
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Tognoni, G.
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visa fler...
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Wikstrand, John, ...
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Kjekshus, J.
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Lip, G. Y.
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Maggioni, A. P.
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Tavazzi, L.
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Lees, K. R.
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McMurray, J. J.
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Göteborgs universitet