Sökning: onr:"swepub:oai:gup.ub.gu.se/223192" >
Genetic Factors in ...
Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis
-
Dongiovanni, P. (författare)
-
- Romeo, Stefano, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Valenti, L. (författare)
-
(creator_code:org_t)
- Hindawi Limited, 2015
- 2015
- Engelska.
-
Ingår i: Biomed Research International. - : Hindawi Limited. - 2314-6133 .- 2314-6141.
- Relaterad länk:
-
http://downloads.hin...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Liver fat accumulation generally related to systemic insulin resistance characterizes nonalcoholic fatty liver disease (NAFLD), which in the presence of nonalcoholic steatohepatitis (NASH) can progress towards cirrhosis and hepatocellular carcinoma. Due to the epidemic of obesity, NAFLD is now the most frequent liver disease in Western countries. Epidemiological, familial, and twin studies provide evidence for a strong genetic component of NAFLD susceptibility. Recently, genome-wide association studies led to the identification of the major inherited determinants of hepatic fat accumulation: patatin-like phospholipase domain-containing 3 (PNPLA3) I148M gene and transmembrane 6 superfamily member 2 (TM6SF2) E167K gene variants, involved in lipid droplets remodelling and very low-density lipoproteins secretion, are the major determinants of interindividual differences in liver steatosis, and susceptibility to progressive NASH. In this review, we aimed to provide an overview of recent insights into the genetics of hepatic fat accumulation and steatohepatitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- CHRONIC HEPATITIS-C
- GREATER-THAN-G
- TRANSPORT PROTEIN 5
- HEPATOCELLULAR-CARCINOMA
- INSULIN-RESISTANCE
- I148M POLYMORPHISM
- METABOLIC SYNDROME
- ADIPOSE-TISSUE
- OBESE CHILDREN
- CONFERS
- SUSCEPTIBILITY
- Biotechnology & Applied Microbiology
- Medicine
- Research & Experimental
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas