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Undetermined stroke...
Undetermined stroke with an embolic pattern-a common phenotype with high early recurrence risk
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Putaala, J. (författare)
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Nieminen, T. (författare)
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Haapaniemi, E. (författare)
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visa fler...
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Meretoja, A. (författare)
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Rantanen, K. (författare)
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Heikkinen, N. (författare)
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Kinnunen, J. (författare)
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Strbian, D. (författare)
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Mustanoja, S. (författare)
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Curtze, S. (författare)
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Pakarinen, S. (författare)
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Lehto, M. (författare)
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- Tatlisumak, Turgut (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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(creator_code:org_t)
- 2015-07-29
- 2015
- Engelska.
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Ingår i: Annals of Medicine. - : Informa UK Limited. - 0785-3890 .- 1365-2060. ; 47:5, s. 406-413
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Introduction. Undetermined strokes with an embolic pattern (USEP) represent a common phenotype. We assessed their frequency and compared USEP with cardioembolic stroke with a known source and non-cardioembolic stroke etiology. Methods. Study patients were 540 consecutive ischemic stroke patients admitted to Helsinki University Hospital with primary end-point of recurrent stroke in a 21-month follow-up. Cox regression adjusting for CHA(2)DS(2)-VASc and anticoagulation estimated the risk of USEP on recurrent stroke. Results. A total of 229 (42.4%) patients had a non-cardioembolic stroke etiology, 184 (34.1%) had a cardioembolic stroke with a known source, and 127 (23.5%) were classified as USEP. USEP patients had less diabetes and prior TIA, with more severe symptoms than the non-cardioembolic stroke cases. They were younger, had fewer comorbidities, and less severe symptoms than the cardioembolic stroke patients. Cumulative risk of recurrent stroke was 10.0% (95% CI 4.1%-15.9%) for USEP, 5.0% (1.1%-8.9%) for cardioembolic strokes, and 5.0% (3.0%-7.0%) for non-cardioembolic strokes (P = 0.089). USEP associated with a higher risk of recurrent stroke compared to non-cardioembolic strokes (hazard ratio 2.36, 95% CI 1.02-5.47; P = 0.046) and cardioembolic stroke with a known source (1.83, 1.07-3.14; P = 0.028). Conclusions. Despite their younger age and more favorable risk factor profile compared with other phenotypes, USEP exhibited a high risk of stroke recurrence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Atrial fibrillation
- mortality
- recurrence
- stroke
- patent foramen ovale
- acute ischemic-stroke
- cryptogenic stroke
- atrial-fibrillation
- cerebral-ischemia
- prognosis
- subtypes
- events
- prevention
- warfarin
- General & Internal Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Putaala, J.
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Nieminen, T.
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Haapaniemi, E.
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Meretoja, A.
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Rantanen, K.
-
Heikkinen, N.
-
visa fler...
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Kinnunen, J.
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Strbian, D.
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Mustanoja, S.
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Curtze, S.
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Pakarinen, S.
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Lehto, M.
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Tatlisumak, Turg ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Annals of Medici ...
- Av lärosätet
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Göteborgs universitet