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Sökning: onr:"swepub:oai:gup.ub.gu.se/227219" > Prediagnostic circu...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06383naa a2201033 4500 | |
| 001 | oai:gup.ub.gu.se/227219 | |
| 003 | SwePub | |
| 008 | 240528s2014 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-88173 | |
| 009 | oai:lup.lub.lu.se:c3df05e2-9d4a-425a-b868-261985678898 | |
| 009 | oai:prod.swepub.kib.ki.se:129876092 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2272192 URI |
| 024 | 7 | a https://doi.org/10.1002/hep.270792 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-881732 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/47963422 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1298760922 URI |
| 040 | a (SwePub)gud (SwePub)umud (SwePub)lud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fedirko, V.4 aut |
| 245 | 1 0 | a Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: A nested case-control study |
| 264 | c 2014-08-28 | |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2014 |
| 520 | a The association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated, despite experimental evidence supporting an important role of vitamin D in liver pathophysiology. Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Each case (n=138) diagnosed between 1992 and 2010 was matched to one control by age, sex, study center, date and time of blood collection, and fasting status. Serum baseline levels of 25(OH)D were measured by liquid chromatography/tandem mass spectrometry. Multivariable incident rate ratios (IRRs) of HCC associated with continuous (per 10 nmol/L) or categorical levels (tertiles or a priori-defined categories) of prediagnostic 25(OH)D were calculated using conditional logistic regression. Higher 25(OH)D levels were associated with a 49% reduction in the risk of HCC (highest versus lowest tertile: multivariable IRR=0.51, 95% confidence interval [CI], 0.26 to 0.99; Ptrend=0.04; per 10 nmol/L increase: IRR=0.80, 95% CI, 0.68-0.94). The finding did not vary substantially by time from enrolment to diagnosis, and did not change after adjustment for biomarkers of preexisting liver damage, nor chronic infection with hepatitis B or C viruses. The findings were not modified by body size or smoking status. Conclusion: In this prospective study on western European populations, serum levels of 25(OH)D were inversely associated with the risk of HCC. Given the rising incidence of this cancer in low-risk developed countries and the strong public health interest surrounding the potentially cancer-protective roles of vitamin D, additional studies in different populations are required. © 2014 by the American Association for the Study of Liver Diseases. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 700 | 1 | a Duarte-Salles, T.4 aut |
| 700 | 1 | a Bamia, C.4 aut |
| 700 | 1 | a Trichopoulou, A.4 aut |
| 700 | 1 | a Aleksandrova, K.4 aut |
| 700 | 1 | a Trichopoulos, D.4 aut |
| 700 | 1 | a Trepo, E.4 aut |
| 700 | 1 | a Tjønneland, A.4 aut |
| 700 | 1 | a Olsen, A.4 aut |
| 700 | 1 | a Overvad, K.4 aut |
| 700 | 1 | a Boutron-Ruault, M. C.4 aut |
| 700 | 1 | a Clavel-Chapelon, F.4 aut |
| 700 | 1 | a Kvaskoff, M.4 aut |
| 700 | 1 | a Kühn, T.4 aut |
| 700 | 1 | a Lukanova, A.4 aut |
| 700 | 1 | a Boeing, H.4 aut |
| 700 | 1 | a Buijsse, B.4 aut |
| 700 | 1 | a Klinaki, E.4 aut |
| 700 | 1 | a Tsimakidi, C.4 aut |
| 700 | 1 | a Naccarati, A.4 aut |
| 700 | 1 | a Tagliabue, G.4 aut |
| 700 | 1 | a Panico, S.4 aut |
| 700 | 1 | a Tumino, R.4 aut |
| 700 | 1 | a Palli, D.4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H. B.4 aut |
| 700 | 1 | a Siersema, P. D.4 aut |
| 700 | 1 | a Peters, P. H.4 aut |
| 700 | 1 | a Lund, E.4 aut |
| 700 | 1 | a Brustad, M.4 aut |
| 700 | 1 | a Olsen, K. S.4 aut |
| 700 | 1 | a Weiderpass, E.u Karolinska Institutet4 aut |
| 700 | 1 | a Zamora-Ros, R.4 aut |
| 700 | 1 | a Malm, Johanu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-jma |
| 700 | 1 | a Ardanaz, E.4 aut |
| 700 | 1 | a Amiano, P.4 aut |
| 700 | 1 | a Navarro, C.4 aut |
| 700 | 1 | a Quirós, J. R.4 aut |
| 700 | 1 | a Werner, Mårtenu Umeå universitet,Medicin4 aut0 (Swepub:umu)manwer04 |
| 700 | 1 | a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
| 700 | 1 | a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo |
| 700 | 1 | a Malm, J.4 aut |
| 700 | 1 | a Travis, R. C.4 aut |
| 700 | 1 | a Khaw, K. T.4 aut |
| 700 | 1 | a Stepien, M.4 aut |
| 700 | 1 | a Scalbert, A.4 aut |
| 700 | 1 | a Romieu, I.4 aut |
| 700 | 1 | a Lagiou, P.4 aut |
| 700 | 1 | a Riboli, E.4 aut |
| 700 | 1 | a Jenab, M.4 aut |
| 710 | 2 | a Karolinska Institutetb Klinisk kemi, Malmö4 org |
| 773 | 0 | t Hepatologyd : Ovid Technologies (Wolters Kluwer Health)g 60:4, s. 1222-1230q 60:4<1222-1230x 0270-9139x 1527-3350 |
| 856 | 4 | u https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.27079 |
| 856 | 4 | u http://dx.doi.org/10.1002/hep.27079y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/227219 |
| 856 | 4 8 | u https://doi.org/10.1002/hep.27079 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88173 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4796342 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129876092 |
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