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Nested PCR for dete...
Nested PCR for detection of HSV-1 in oral mucosa
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- Jalouli, Miranda (författare)
- Uppsala universitet,Käkkirurgi
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- Jalouli, Jamshid (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Käkkirurgi
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- Hasséus, Bengt, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 1,Institute of Odontology, Section 1
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Öhman, J. (författare)
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- Hirsch, Jan M (författare)
- Uppsala universitet,Käkkirurgi
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- Sand, Lars (författare)
- Uppsala universitet,Käkkirurgi
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(creator_code:org_t)
- Medicina Oral, S.L. 2015
- 2015
- Engelska.
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Ingår i: Medicina Oral, Patologia Oral y Cirugia Bucal. - : Medicina Oral, S.L.. - 1698-4447 .- 1698-6946. ; 20:6
- Relaterad länk:
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https://doi.org/10.4...
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https://gup.ub.gu.se...
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https://doi.org/10.4...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- © Medicina Oral S. L. Background: It has been estimated that 15%-20% of human tumours are driven by infection and inflammation, and viral infections play an important role in malignant transformation. The evidence that herpes simplex virus type 1 (HSV-1) could be involved in the aetiology of oral cancer varies from weak to persuasive. This study aimed to investigate by nested PCR (NPCR) the prevalence of HSV-1 in samples from normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma (OSCC). Material and Methods: We investigated the prevalence of HSV-1 in biopsies obtained from 26 fresh, normal oral mucosa from healthy volunteers as well as 53 oral leukoplakia and 27 OSCC paraffin-embedded samples. DNA was extracted from the specimens and investigated for the presence of HSV-1 by nested polymerase chain reaction (NPCR) and DNA sequencing. Results: HSV-1 was detected in 14 (54%) of the healthy samples, in 19 (36%) of the oral leukoplakia samples, and in 14 (52%) of the OSCC samples. The differences were not statistically significant. Conclusions: We observed a high incidence of HSV-1 in healthy oral mucosa, oral leukoplakia, and OSCC tissues. Thus, no connection between OSCC development and presence of HSV-1 was detected.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- HSV-1
- Nested PCR
- PCR
- HSV-1; nested PCR; PCR
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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